Browsing Microbiology and Immunology by Author "Spartà, Antonino Maria"
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PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors
Lonetti, Annalisa; Cappellini, Alessandra; Spartà, Antonino Maria; Chiarini, Francesca; Buontempo, Francesca; Evangelisti, Camilla; Evangelisti, Cecilia; Orsini, Ester; McCubrey, James A.; Martelli, Alberto M. (2015-04)Class I phosphatidylinositol 3-kinases (PI3Ks) are frequently activated in T-cell acute lymphoblastic leukemia (T-ALL), mainly due to the loss of PTEN function. Therefore, targeting PI3Ks is a promising innovative approach ...