Search
Now showing items 1-7 of 7
Unique V3 Loop Sequence Derived from the R2 Strain of HIV-Type 1 Elicits Broad Neutralizing Antibodies
(East Carolina University, 2004-11)
DNA vaccines expressing the envelope (Env) of the human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies. In this
study, DNA vaccines ...
Base-By-Base: Single nucleotide-level analysis of whole viral genome alignments
(East Carolina University, 2004-07-14)
Background: With ever increasing numbers of closely related virus genomes being sequenced, it has become desirable to be able to compare two genomes at a level more detailed than gene content because two strains of an ...
Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection
(East Carolina University, 2004-12)
Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of ...
A Multicomponent System Is Required for Tetracycline-Induced Excision of Tn4555
(East Carolina University, 2004-01)
Bacteroides spp. are the predominant organisms in the intestinal tract, and they also are important opportunistic
pathogens. Antibiotic therapy of Bacteroides infections often is complicated by the prevalence of
drug-resistant ...
Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model
(East Carolina University, 2004-08)
Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display ...
Pseudomonas aeruginosa relA Contributes to Virulence in Drosophila melanogaster
(East Carolina University, 2004-10)
The stringent response is a mechanism by which bacteria adapt to nutritional deficiencies through the production of the guanine nucleotides ppGpp and pppGpp, produced by the RelA enzyme. We investigated the role of the ...
Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids
(East Carolina University, 2004-04-06)
Sinorhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen, both require the bacterial-encoded BacA protein to establish chronic intracellular infections in their respective ...