Browsing Biology by Author "Georgakilas, Alexandros G."

Now showing items 1-6 of 6

  • Analysis of Complex DNA Damage Associated with Tumor Growth 

    Ferguson, Nicholas Foster (East Carolina University, 2012)
    The innate response of a fully functioning immune system's ability to recognize and react to the growth of a tumor by releasing reactive oxygen species (ROS) may lead to chronic inflammation in many cases. This chronic ...

  • Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins 

    Sideridou, Maria; Zakopoulou, Roubini; Evangelou, Konstantinos; Liontos, Michalis; Kotsinas, Athanassios; Rampakakis, Emmanouil; Gagos, Sarantis; Kahata, Kaoru; Grabusic, Kristina; Gkouskou, Kalliopi; Trougakos, Ioannis P.; Kolettas, Evangelos; Georgakilas, Alexandros G.; Volarevic, Sinisa; Eliopoulos, Aristides G.; Zannis-Hadjopoulos, Maria; Moustakas, Aristidis; Gorgoulis, Vassilis G. (2011-12)
    E-cadherin (CDH1) loss occurs frequently in carcinogenesis, contributing to invasion and metastasis. We observed that mouse and human epithelial cell lines overexpressing the replication licensing factor Cdc6 underwent ...

  • Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective 

    Kalogerinis, Peter T.; Poulos, John E.; Morfesis, Andrew; Daniels, Anthony; Georgakila, Stavroula; Daignualt, Thomas; Georgakilas, Alexandros G. (2010)
    Background There is very small occurrence of adenocarcinoma in the small bowel. We present a case of primary duodenal adenocarcinoma and discuss the findings of the case diagnostic modalities, current knowledge on the ...

  • Processing of bistranded abasic DNA clusters in γ-irradiated human hematopoietic cells 

    Georgakilas, Alexandros G.; Bennett, Paula V.; Wilson III, David M.; Sutherland, Betsy M. (East Carolina University, 2004)
    Clustered DNA damages—two or more lesions on opposing strands and within one or two helical turns—are formed in cells by ionizing radiation or radiomimetic antitumordrugs. They are hypothesized to be difficult to repair, ...

  • Repair of Clustered DNA Lesions in Double Strand Break Repair Deficient Human Tumor Cells 

    Loftin, Charles William (East Carolina University, 2010)
    DNA-dependent protein kinase (DNA-PK) is a holoenzyme of three subunits, Ku70, Ku80, and the DNA-Pk catalytic subunit (DNA-PKcs). DNA-PK serves a role in non-homologous end joining to repair double stranded breaks, and ...

  • Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo 

    Kryston, Thomas (East Carolina University, 2010)
    Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ...