Browsing Biology by Author "Scemama, Jean-Luc"
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Analysis of Myopodin in Hela Cervical Carcinoma Cells
Harkins, Melissa (East Carolina University, 2014)Synaptopodin-2 is a proline-rich, actin-binding protein that exists in many isoforms. Due to its large proline content, synaptopodin-2 exists in a naturally unfolded state and possesses the characteristics of a hub protein. ... -
Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution
Chiu, Chi-hua; Dewar, Ken; Wagner, Gunter P.; Takahashi, Kazuhiko; Ruddle, Frank; Ledje, Christina; Bartsch, Peter; Scemama, Jean-Luc; Stellwag, Edmund; Fried, Claudia; Prohaska, Sonja J.; Stadler, Peter F.; Amemiya, Chris T. (East Carolina University, 2004-01)The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish possess duplicated Hox ... -
Bioinformatic exploration of Hoxa2, Hoxb2, Hoxa11, and Hoxd11 in vertebrate evolution
Carr, Kari (2015)The purpose of this bioinformatic project was to develop an understanding of how gene evolution shaped morphological complexity within the vertebrate lineage by evaluating protein sequence variations within hoxa2, hoxb2, ... -
CHARACTERIZATION OF MIGRATING NEURAL CREST CELLS FROM HINDBRAIN EXPLANTS IN ZEBRAFISH
Murolo, Daniel (East Carolina University, 2010)Our lab was interested in creating a reproducible mechanism for obtaining neural crest cells in culture from cultured hindbrain explants of zebrafish. We have characterized the population of cells migrating from the ... -
Characterizing Interactions of Thioflavin-T with Native Proteins Especially Bovine Serum Albumin
Stratton, Caleb Matthew (East Carolina University, 2017-05-03)Thioflavin T is a fluorescent probe used to monitor formation of cross [beta]-sheet rich amyloid fibrils. Involvement of the amyloid fibrils is implicated in more than 50 human diseases, such as Alzheimer's, Parkinson's ... -
The Effects of Gastrin and Hox-A1 on HT-29 Cell Proliferation
White, Daniel (East Carolina University, 2013)Gastrin is a gastrointestinal peptide hormone synthesized in G cells and secreted in the antrum of the stomach. Though its primary role is to stimulate the secretion of gastric acid by parietal cells, it is also involved ... -
The effects of sodium butyrate on Hox gene expression in a human colorectal adenocarcinoma cell line, HT29.
Conaty, Lucy D. (East Carolina University, 2013)Hox genes are a subgroup of the large family of homeobox containing genes, known to pattern anterior/posterior and proximal/distal axes during embryonic development. More recently Hox gene research has focused on the role ... -
Exploring the Potential of Sucralose as a Cryopreservative for Red Blood Cells
Holloman, Matthew (East Carolina University, 2017-12-11)Cryopreservation is a technique that involves freezing living cells to preserve them in long-term storage. Freezing and preserving living cells would not be possible without the assistance of cryopreservatives. Many ... -
Hox Gene Expression During Oreochromis niloticus Pharyngeal Arch Development : Discovering the Hox Code
Lyon, Raymond Stewart (East Carolina University, 2010)Hox genes encode transcription factors and have been extensively studied by evolutionary and developmental biologists. Hox genes are responsible for determining specific regional identities along the anterior-posterior and ... -
SYNAPTOPODIN-2 ISOFORM A AND D EXPRESSION IN HT-29 HUMAN COLON ADENOCARCINOMA CELLS
Shortt, Kelli A. (East Carolina University, 2013)Synaptopodin-2 is a largely unfolded actin-binding protein that also possesses the characteristics of a hub protein. Synaptopodin-2 has other known binding partners such as filamin and [alpha]-actinin (Weins, et al. 2001 ...