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The largest subunit of RNA polymerase II from the Glaucocystophyta: functional constraint and short-branch exclusion in deep eukaryotic phylogeny
(East Carolina University, 2005-12)
Background: Evolutionary analyses of the largest subunit of RNA polymerase II (RPB1) have yielded important and at times provocative results. One particularly troublesome outcome is the consistent inference of independent ...
Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line
(East Carolina University, 2008-10)
Bcl-2 is an anti-apoptotic protein that is frequently overex-pressed in cancer cells but its role in
carcinogenesis is not clear. We are interested in how Bcl-2 expression affects non-cancerous breast
cells and its role ...
The Manganese Transporter MntH Is a Critical Virulence Determinant for Brucella abortus 2308 in Experimentally Infected Mice
(East Carolina University, 2009-08)
The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to encode the manganese transporter MntH. Phenotypic analysis of an isogenic mntH mutant indicates that MntH is the sole high-affinity ...
A Müllerian mimicry ring in Appalachian millipedes
(East Carolina University, 2009-06-16)
Few biological phenomena provide such an elegant and straightforward
example of evolution by natural selection as color mimicry among unrelated organisms. By mimicking the appearance of a heavily defended aposematic ...
Amazonian Amphibian Diversity Is Primarily Derived from Late Miocene Andean Lineages
(East Carolina University, 2009-03)
The Neotropics contains half of remaining rainforests and Earth’s largest reservoir of amphibian biodiversity. However, determinants of Neotropical biodiversity (i.e., vicariance, dispersals, extinctions, and radiations) ...
Are algal genes in nonphotosynthetic protists evidence of historical plastid endosymbioses?
(East Carolina University, 2009)
Background: How photosynthetic organelles, or plastids, were acquired by diverse eukaryotes is among the most hotly debated topics in broad scale eukaryotic evolution. The history of plastid endosymbioses commonly is ...
Adaptive evolution of genes underlying schizophrenia
(East Carolina University, 2007-11-22)
Schizophrenia poses an evolutionary-genetic paradox because it exhibits strongly negative fitness effects and high heritability, yet it persists at a prevalence of approximately 1% across all human cultures. Recent theory ...
Catabolite repression control (Crc) gene and Pseudomonas virulence
(2004-11-30)
The present invention relates to a method of screening for compounds that inhibit the virulence of Pseudomonas bacteria and comprises the steps of: providing a culture medium comprising Pseudomonas bacteria, administering ...
Gamma Protocadherin Expression in the Embryonic Chick Nervous System
(East Carolina University, 2007)
Protocadherin gamma (pcdh-gamma) family expression was examined in the embryonic chick central nervous system by in situ hybridization. Transcripts were visualized in discrete regions of fore-, mid-, and hindbrain at stages ...
Footprints in the sand: independent reduction of subdigital lamellae in the Namib–Kalahari burrowing geckos
(East Carolina University, 2006-04-07)
Many desert organisms exhibit convergence, and certain physical factors such as windblown sands have generated remarkably similar ecomorphs across divergent lineages. The burrowing geckos Colopus, Chondrodactylus and ...