Browsing Chemistry by Type"Master's Thesis"
Now showing items 21-40 of 74
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Elucidating "Consumption" : Using Fluorescent Steroid Probes to Understand Host Cholesterol Utilization by Mycobacterium spp.
(East Carolina University, 2014)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, is the leading cause of death due to bacterial infection worldwide, claiming nearly two million lives each year. Often, the immune system ... -
EXPLORATION INTO THE SCOPE AND MECHANISM OF THE PLATINUM-CATALYZED ACYLATION OF 2-(ARYLOXY)PYRIDINES
(East Carolina University, 2019-07-11)Transition metal catalysts have played a key role in direct C-H bond functionalization. However, one main drawback of these reactions is that oxidants and additives are often required to regenerate the active catalyst, ... -
EXPLORING STUDENT EXPERIENCES ACROSS A LINKED SEQUENCE COURSE-BASED UNDERGRADUATE RESEARCH EXPERIENCE
(East Carolina University, 2020-11-23)This study reports the effect a linked Course-based Undergraduate Research Experience (CURE) has on a students' understanding of research and the associated experiences they encountered. CUREs offer an alternative path to ... -
Fluorescent Derivatives of Prostamides: Tools for Studying Anti-Cancer Activity
(East Carolina University, 2018-07-23)The endocannabinoid arachidonoyl ethanolamide (AEA) and prostaglandins derived from it selectively induce apoptosis in tumorigenic cell lines due to overexpression of COX-2. It is likely that a novel J-series prostamide, ... -
GRADUATE TEACHING ASSISTANT FIDELITY OF IMPLEMENTATION IN INTRODUCTORY CHEMISTRY AND PHYSICS LABORATORIES: IMPACT ON SCIENCE PRACTICE PROFICIENCY
(East Carolina University, 2020-06-22)This study reports the fidelity of implementation of the Argument-Driven Inquiry (ADI) instructional model by graduate teaching assistants (GTAs) in introductory chemistry and introductory physics laboratories at East ... -
HOW CHARGED RESIDUES INFLUENCE THE THERMAL STABILITY OF COLLAGEN: A STUDY WITH NATURAL AND NON-NATURAL AMINO ACIDS
(East Carolina University, 2020-09-16)Triple-helical collagens are key structural proteins in mammals. Their ubiquity and diverse functions drive our interest into understanding their behavior at a fundamental level. This thesis describes a reductionist approach ... -
IDENTIFICATION OF NOVEL CYTOTOXIC PROSTAGLANDIN METABOLITES PRODUCED IN ARACHIDONOYL ETHANOLAMIDE-TREATED TUMOREGENIC KERATINOCYTES
(East Carolina University, 2012)Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). Our previous data show that AEA is metabolized by COX-2 to pro-apoptotic J-series prostaglandins. COX-2 is an enzyme that ... -
Identifying compensatory genomic changes due to nickel (Ni2+) exposure: electrochemistry and quantifying DNA damage
(East Carolina University, 2020-11-24)Nickel is a toxic heavy metal that has been shown to cause adverse healthconditions in organisms. DNA damage has been observed in nematodes in response to nickel exposure. Nematodes originating from environments with high ... -
Improving Prostamide Anti-Cancer Activity Through Derivatization and Micellar Delivery
(East Carolina University, 2023-04-28)Colorectal cancer is the fourth most common cancer diagnosis per year as well as the fourth highest rate of death per year according to the Centers for Disease Control. Approximately 1/3rd of the diagnosed colorectal cancer ... -
Improving the Reliability of Peptide-Zinc (II) Binding Constant Determination with Mass Spectrometry
(East Carolina University, 2012)Electrospray Ionization Mass Spectrometry (ESI-MS) has become a powerful technique for analyzing protein- and peptide-ligand interactions and quantifying their binding constants (K[subscript]b). However, ESI-MS as an ... -
Investigating Intra- and Inter-Molecular Coevolution of Intrinsically Disordered Protein, Prothymosin-alpha
(East Carolina University, 1/13/16)Prothymosin-α (ProTα) is a small, highly acidic protein found in the nuclei of virtually all mammalian tissues. It belongs to a class of proteins known for their lack of a rigid three-dimensional structure called intrinsically ... -
Investigation Into The Scope, Limitations, And Mechanistic Aspects Of A Regioselective Acylation Of Cycloplatinated Complexes
(East Carolina University, 2015)In the reaction of N-isopropyl-N-phenyl-2,2'-bipyridin-6-amine with potassium tetrachloroplatinate, the selective C-H bond activation was complicated by the low selectivity of sp² C-H bond activation in acetonitrile and ... -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
(East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
Investigation of possible driving forces on counter-intuitive thermal collapse of intrinsically disordered proteins
(East Carolina University, 2016-08-18)Intrinsically disordered proteins are an emerging class of proteins that contain no secondary or tertiary structure. Through bioinformatics studies it has been predicted that a third of the human proteome consists of ... -
Kinetic Modeling of Batch Reaction Processes
(East Carolina University, 2012)Kinetic models have been demonstrated to be useful in on-line batch monitoring systems. The ability to monitor a reaction in real time is invaluable to the production process of industrial and pharmaceutical products. ... -
KINETIC MODELING OF DISSOLUTION AND CRYSTALLIZATION OF BATCH REACTIONS WITH IN SITU SPECTROSCOPIC MEASUREMENTS
(East Carolina University, 2012)The use of Process Analytical Technology (PAT) recommended by the Food and Drug Administration (FDA) has significantly increased during the past years in the design, control and monitoring of pharmaceutical or chemical ... -
Method Development and Validation for the Rapid Detection of Organophosphates in Blood Plasma from Obese, Obese-Diabetic, and Lean Patients from Eastern North Carolina
(East Carolina University, 2017-07-13)The incidence of diabetes and rate of obesity is on the rise, along with the use of organophosphorus insecticides in the United States. Organophosphates (OP), a specific class of pesticide that is biodegradable and readily ... -
Molecular Dynamics Studies of Point Mutations of Cardiac Troponin C and Annexin
(East Carolina University, 2015)Calcium binding proteins are biologically important for their ability to convert changes in calcium ion concentration to functional changes in proteins. All calcium binding proteins use a calcium sensing motif that changes ... -
A Molecular Dynamics Study into Annexin A1 Induced Membrane Binding and Aggregation
(East Carolina University, 2010)Annexins constitute a family of proteins that bind to anionic membranes in a reversible and calcium dependent manner through the unique architecture of their calcium binding sites. In addition, annexins with relatively ... -
NMR Studies into the Potential Interactions of Fullerene C[subscript]60, with Tetraphenylporphyrin, H[subscript]2[TPP] and Some of its Derivatives
(East Carolina University, 2011)The curved [pi] surface of fullerene, C[subscript]60, shows a tendency to interact with other molecules, making it an interesting target for building supramolecular arrays. The interaction can be relative strong and may ...