Now showing items 1-2 of 2

  • Elucidating the Mechanisms of Transthyretin Aggregation in Transthyretin Amyloidosis 

    Dasari, Anvesh K. R (East Carolina University, 2018-07-24)
    Accumulation of insoluble aggregates (amyloids) is a characteristic feature of many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Aggregation and deposition of Transthyretin (TTR) protein ...
  • NMR characterizations of an amyloidogenic conformational ensemble of the PI3K SH3 domain 

    Ahn, Hee-Chul; Le, Yen T. H.; Nagchowdhuri, Partha S.; Derose, Eugene F.; Putnam-Evans, Cindy; London, Robert E.; Markley, John L.; Lim, Kwang Hun (East Carolina University, 2006-11)
    Amyloid formation is associated with structural changes of native polypeptides to monomeric intermediate states and their self-assembly into insoluble aggregates. Characterizations of the amyloidogenic intermediate state ...