Browsing Other Campus Research by Title
Now showing items 739-758 of 1103
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Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle
(2020-04-21)Peroxisomes are essential for lipid metabolism and disruption of liver peroxisomal function results in neonatal death. Little is known about how peroxisomal content and activity respond to changes in the lipid environment ... -
Persistent akathisia masquerading as agitated depression after use of ziprasidone in the treatment of bipolar depression
(2013-04-04)There has been increasing recognition that the second-generation antipsychotic drugs can produce extrapyramidal side effects. This case reports the development of severe akathisia in a patient being treated with ziprasidone ... -
Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish
(2018-09-24)Recent investigations suggest progestin receptor membrane component 1 (PGRMC1) associates with and transports a wide range of molecules such as heme, cytochromes P450, steroids with 21 carbons, membrane progestin receptor ... -
Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish
(2018-09-24)Recent investigations suggest progestin receptor membrane component 1 (PGRMC1) associates with and transports a wide range of molecules such as heme, cytochromes P450, steroids with 21 carbons, membrane progestin receptor ... -
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)PURPOSE: Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ... -
Phenotypic and Genetic Divergence among Poison Frog Populations in a Mimetic Radiation
(2013-02-06)The evolution of Müllerian mimicry is, paradoxically, associated with high levels of diversity in color and pattern. In a mimetic radiation, different populations of a species evolve to resemble different models, which can ... -
Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells
(2012-02-07)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ... -
Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program
(2011-05-12)FOG-3, the single Caenorhabditis elegans Tob/BTG protein, directs germ cells to adopt the sperm fate at the expense of oogenesis. Importantly, FOG-3 activity must be maintained for the continued production of sperm that ... -
Photodynamic Therapeutic Effect of Nanostructured Metal Sulfide Photosensitizers for Cancer Treatment
(2022-03-08)Photodynamic therapy (PDT) utilizes photosensitizers (PSs) to produce reactive oxygen species (ROSs) upon irradiation, which causes the shutdown of vessels and deprives the tumor of nutrients and oxygen, and in turn induces ... -
Photoplethysmographic imaging and analysis of pulsatile pressure wave in palmar artery at 10 wavelengths
(2022-11-10)Significance As a noncontact method, imaging photoplethysmography (iPPG) may provide a powerful tool to measure pulsatile pressure wave (PPW) in superficial arteries and extract biomarkers for monitoring of artery wall ... -
Phylogenomic Reconstruction of the Neotropical Poison Frogs (Dendrobatidae) and Their Conservation
(2019-01-29)The evolutionary history of the Dendrobatidae, the charismatic Neotropical poison frog family, remains in flux, even after a half-century of intensive research. Understanding the evolutionary relationships between dendrobatid ... -
Physical activity is reduced prior to ventricular arrhythmiasin patients with a wearable cardioverter defibrillator
(2019-10-23)The utility of accelerometer‐based activity data to identify patients at risk of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) has not previously been investigated. The aim of the current study ... -
Physical Activity Levels in Urban-Based South African Learners: A Cross-Sectional Study of 7 348 Participants
(2018-02-01)Background: Establishing profiles of physical activity (PA) is critical in tackling the chronic diseases associated with lack of PA and avoiding healthcare costs. Objective: To investigate PA levels in urban-based South ... -
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
(2017-02-20)B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ... -
PI3K mediated activation of GSK‑3β reduces at‑level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias
(2015-06-21)Background Neuropathic pain and sensory abnormalities are a debilitating secondary consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining recognition for its role in contributing to the ... -
A pilot project to increase health literacy among youth from seasonal farmworker families in rural eastern North Carolina: a qualitative exploration of implementation and impact
(2019-04)Objective There are substantial health inequalities for seasonal agricultural workers and their families in the United States. One identified inequality is in health literacy. The authors explored the implementation and ... -
Pineal Region Glioblastoma, a Case Report and Literature Review
(2017-06-12)Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with ... -
Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome
(2016-05)Glucocorticoids are the primary therapy for nephrotic syndrome (NS), but have serious side effects and are ineffective in ~20-50% of patients. Thiazolidinediones have recently been suggested to be renoprotective, and to ... -
Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome
(2018-01-08)The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic system, a presynaptic hyperdopaminergic state, seem ...