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Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: Two randomized controlled trials
(2011-08-17)
Context Patients with chronic disabling gout refractory to conventional urate-lowering therapy need timely treatment to control disease manifestations related to tissue urate crystal deposition. Pegloticase, monomethoxyp ...
Diversity of the arctic deep-sea benthos
(2011-02-11)
A benthic species inventory of 1,125 taxa was compiled from various sources for the central Arctic deeper than 500 m, and bounded to the Atlantic by Fram Strait. The inventory was dominated by arthropods (366 taxa), ...
Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax
(2011-08-18)
Adult T-cell leukemia (ATL) is one of the primary diseases caused by Human T-cell Leukemia Virus type 1 (HTLV-1) infection. The virally-encoded Tax protein is believed to initiate early events in the development of this ...
Divergent roles of superoxide and nitric oxide in liver ischemia and reperfusion injury
(2011)
Liver ischemia and reperfusion-induced injury is a major clinical complication associated with hemorrhagic or endotoxin shock and thermal injury as well as liver transplantation and resectional surgery. Data obtained from ...
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells
(2011-08-30)
Escape from cellular senescence induction is a potent mechanism for chemoresistance. Cellular senescence can be induced in breast cancer cell lines by the removal of estrogen signaling with tamoxifen or by the accumulation ...
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α<inf>2</inf>β <inf>1</inf>in mice
(2011)
OBJECTIVE:
The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through ...
Coronary artery ligation and intramyocardial injection in a murine model of infarction
(2011-06-07)
Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo . With the advent of genetic modifications to the whole organism or the myocardium and an array of biological ...
Diabetic muscle infarction: A rare complication of long-standing and poorly controlled diabetes mellitus
(2011-10-09)
Objective. To report a case of diabetic muscle infarction (DMI), a rare complication of long-standing poorly controlled diabetes mellitus. Methods. We describe a case of a 45-year-old male with an approximately 8-year ...
Conspecific brood parasitism in the tropics: An experimental investigation of host responses in common moorhens and American purple gallinules
(2011-08-03)
Species occupying a broad latitudinal range may show greater phenotypic plasticity in behavior than species with smaller ranges or more specific habitat requirements. This study investigates for the first time the occurrence ...
A multi-sensor approach to examining the distribution of total suspended matter (TSM) in the Albemarle-Pamlico Estuarine System, NC, USA
(2011)
For many coastal waters, total suspended matter (TSM) plays a major role in key biological, chemical and geological processes. Effective mapping and monitoring technologies for TSM are therefore needed to support research ...