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Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
(2017-02)
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ...
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
(2017-01-27)
Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ...
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
(2017-09-08)
Morphological changes in apoptotic cells provide essential markers for defining and detec- tion of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have ...
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
(2017-12)
Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ...
Tumor Microenvironment and Metabolism
(2017-12-16)
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the ...