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Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
(2015)
Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation,
for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis,
referred to as the “Warburg effect”, commonly ...
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
(2015)
Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a ...
Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I
(2015)
he mitochondrial electron transport system (ETS) is responsible for setting and
maintaining both the energy and redox charges throughout the cell. Reversible
phosphorylation of mitochondrial proteins, particularly via ...
Nuclear progestin receptor (Pgr) knockouts in zebrafish demonstrate role for Pgr in ovulation but not in rapid non-genomic steroid mediated meiosis resumption
(2015)
Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final
oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes
to become fertilizable eggs in ...
Remote Antimicrobial Stewardship in Community Hospitals
(2015-11)
Antimicrobial stewardship has become standard practice at university medical centers, but the practice is more difficult to implement in remote community hospitals that lack infectious diseases trained practitioners. ...
eHealth Literacy and Web 2.0 Health Information Seeking Behaviors Among Baby Boomers and Older Adults
(2015-03-17)
Background: Baby boomers and older adults, a subset of the population at high risk for chronic disease, social isolation, and poor health outcomes, are increasingly utilizing the Internet and social media (Web 2.0) to ...
Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value
(2015)
Long noncoding RNAs (lncRNAs) have recently been found to play important roles in various cancer types. The elucidation of genome-wide lncRNA expression patterns in metastatic nasopharyngeal carcinoma (NPC) could reveal ...
Lack of K-Dependent Oxidative Stress in Cotton Roots Following Coronatine-Induced ROS Accumulation.
(2015)
Coronatine [COR] is a novel type of plant growth regulator with similarities in structure and property to jasmonate. The objective of this study was to examine the relationship between increased root vitality induced by ...
Memory of Germinant Stimuli in Bacterial Spores
(2015-11)
Bacterial spores, despite being metabolically dormant, possess the remarkable capacity to detect nutrients and other molecules in their environment through a biochemical sensory apparatus that can trigger spore germination, ...