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Control of vascular smooth muscle cell growth by connexin 43
(2012-06-21)
Connexin 43 (Cx43), the principal gap junction protein in vascular smooth muscle cells (VSMCs), regulates movement of ions and other signaling molecules through gap junction intercellular communication (GJIC) and plays ...
Inhibition of vascular smooth muscle growth via signaling crosstalk between amp-activated protein kinase and camp-dependent protein kinase
(2012-10-29)
Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ...
Nectin like -5 overexpression correlates with the malignant phenotype in cutaneous melanoma
(2012-08-26)
NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant ...
Organic matter characterization and decomposition dynamics in sub-Antarctic streams impacted by invasive beavers
(2012-11)
Despite being a relatively remote and well conserved area, the sub-Antarctic ecoregion faces pressing global threats from climate change, the ozone hole and introduced species. Its freshwater ecosystems are one of the least ...
Is field of study or location associated with college students' snacking patterns?
(2012)
Objective. To compare on- and off-campus snacking patterns among college students pursuing degrees in health-related fields (HRFs) and nonhealth-related fields (NHRFs). Materials and Methods. Snack frequency questionnaire, ...
Mediastinal neoplasms in patients with Graves disease: A possible link between sustained hyperthyroidism and thymic neoplasia'
(2012-07-23)
BACKGROUND: Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism. ...
Two hits are better than one: Targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-05-04)
Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ...
Targeted therapy for hepatocellular carcinoma: Novel agents on the horizon
(2012-03-31)
Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ...
Validation of food store environment secondary data source and the role of neighborhood deprivation in Appalachia, Kentucky
(2012-08-22)
Background Based on the need for better measurement of the retail food environment in rural settings and to examine how deprivation may be unique in rural settings, the aims of this study were: 1) to validate one commercially ...
Resveratrol inhibits KSHV reactivation by lowering the levels of cellular Egr-1
(2012-03-12)
In the field of herpesvirus research, the exact molecular mechanism by which such viruses reactivate from latency remains elusive. Kaposi's sarcoma-associated herpesvirus (KSHV) primarily exists in a latent state, while ...