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Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
(2016-03-25)
Background
Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accu- mulation of genetic and ...
Commentary: Effect of Skeletal Muscle Native Tropomyosin on the Interaction of Amoeba Actin with Heavy Meromyosin
(2016-08-31)
Keywords: troponin, tropomyosin, cardiomyopathy, troponin T, mutations
Troponin-tropomyosin inhibits skeletal and cardiac muscle contraction at low Ca
rigor-type myosin S1 to actin-tropomyosin-troponin, particularly at ...
Before-school running/walking club: Effects on student on-task behavior
(2016-02-01)
Before-school programs provide a good opportunity for children to engage in physical activity (PA) as well as im- prove their readiness to learn. The purpose of this study was to examine the effect of a before-school ...
Compact NMR relaxometry of human blood and blood components
(2016-10)
Nuclear magnetic resonance relaxometry is a uniquely practical and versatile implementation of NMR technology. Because it does not depend on chemical shift resolution, it can be performed using low- field compact instruments ...
Comparative Transcriptomics of Strawberries (Fragaria spp.) Provides Insights into Evolutionary Patterns
(2016-12-15)
Multiple closely related species with genomic sequences provide an ideal system for studies on comparative and evolutionary genomics, as well as the mechanism of speciation. The whole genome sequences of six strawberry ...
Comprehensive analysis of TCP transcription factors and their expression during cotton (Gossypium arboreum) fiber early development
(2016-02-09)
TCP proteins are plant-specific transcription factors implicated to perform a variety of physiological functions during plant growth and development. In the current study, we performed for the first time the comprehensive ...
Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer
(2016-11-08)
Bladder cancer is one of the leading cancer of the urinary tract. It is often diagnosed at advanced stage of the disease. To date, no specific and effective early detection biomarkers are available. Cancer development and ...
Combining ultrasonography and noncontrast helical computerized tomography to evaluate Holmium laser lithotripsy
(2016-11-14)
The purpose of the study was to establish a mathematical model for correlating the combination of ultrasonography and noncontrast helical computerized tomography (NCHCT) with the total energy of Holmium laser lithotripsy.
In ...
Evolutionary Dynamics of Floral Homeotic Transcription Factor Protein–Protein Interactions
(2016-02-22)
Protein–protein interactions (PPIs) have widely acknowledged roles in the regulation of development, but few studies have addressed the timing and mechanism of shifting PPIs over evolutionary history. The B-class MADS-box ...
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
(2016-01-25)
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for
cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent ...