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N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
(2018-07-27)
The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ...
Emerging role of immune checkpoint blockade in pancreatic cancer
(2018-11-07)
Immune checkpoint blockade (ICB) with programmed cell death protein-1(PD-1)/programmed death ligand -1(PD-L1) antibodies has revolutionized the management of several cancers, especially non-small cell lung cancer, melanoma, ...
Lack of complex type N-glycans lessens aberrant neuronal properties
(2018-06)
Modifications in surface glycans attached to proteins via N-acetylglucosamine-β1-Nasparagine linkage have been linked to tumor development and progression. These modifications include complex N-glycans with high levels of ...
TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
(2018-11-28)
Type 2 diabetes (DM2) constitutes 90%–95% of the diabetes cases and is increasing at an alarming rate in the world. The Centers for Disease Control and Prevention (CDC) estimates that more than 29 million people in the ...
Profile of Public Health Leadership
(2018-09)
Outer Banks Tourists' Preferences, Sensitivities, and Environmental Perceptions: A Case Study of Cape Hatteras National Seashore
(East Carolina University, 2018-07-17)
Tourism is the driving economic force for North Carolina's Outer Banks, attracting millions of visitors every year. However, through the combined effects of increased human activity and development, storms, sea level rise, ...
protaTETHER – a method for the incorporation of variable linkers in protein fusions reveals impacts of linker flexibility in a PKAc‐GFP fusion protein
(2018-03-14)
Protein fusions are of fundamental importance in the study of cellular biology and the elucidation of cell signaling pathways, and the importance of linkers for the proper function of protein fusions is well documented in ...
Sustainability Attitudes of College Students as Future Business Leaders
(East Carolina University, 2018-05-03)
Limited time and finite resources are motivating firms to make significant changes in policy and business practices to maintain profits, sustain the environment, and further a companies’ strategic goals. Managers now value ...
Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review
(2018-03-21)
Background: Healthcare-acquired hypernatremia (serum sodium >145 mEq/dL) is common among critically ill and other
hospitalized patients and is usually treated with hypotonic fluid and/or diuretics to correct a “free water ...