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Now showing items 11-20 of 101
Examining signals of trust in criminal markets online
(2016-09-14)
This study examines the signals of trust in stolen data advertisements by analysing the structural and situational factors that influence the type of feedback sellers receive. Specifically, this article explores the factors ...
Essential role of proteasomes in maintaining self-renewal in neural progenitor cells
(2016-01-25)
Protein turnover and homeostasis are regulated by the proteasomal system, which is critical for
cell function and viability. Pluripotency of stem cells also relies on normal proteasomal activity that mitigates senescent ...
Failure patterns and survival outcomes in triple negative breast cancer (TNBC): a 15 year comparison of 448 non-Hispanic black and white women
(2016-06-17)
Purpose: Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer with unique pathologic, molecular and clinical behavior. It occurs more frequently in young blacks and has been reported to have a shorter ...
Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia
(2016-02-08)
Craniofacial microsomia (CFM) is a rare congenital anomaly that involves immature derivatives from the first and second pharyngeal arches. The genetic pathogenesis of CFM is still unclear. Here we interrogate 0.9 million ...
Genetic Architecture of Conspicuous Red Ornaments in Female Threespine Stickleback
(2016-03)
Explaining the presence of conspicuous female ornaments that take the form of male-typical traits has been a longstanding challenge in evolutionary biology. Such female ornaments have been proposed to evolve via both ...
Functional and Comparative Genomics of Hoxa2 Gene cis-Regulatory Elements: Evidence for Evolutionary Modification of Ancestral Core Element Activity
(2016-03-26)
Hoxa2 is an evolutionarily conserved developmental regulatory gene that functions to specify rhombomere (r) and pharyngeal arch (PA) identities throughout the Osteichthyes. Japanese medaka (Oryzias latipes) hoxa2a, like ...
Gene Regulatory Evolution During Speciation in a Songbird
(2016-03-10)
Over the last decade, tremendous progress has been made toward a comparative un- derstanding of gene regulatory evolution. However, we know little about how gene regulation evolves in birds, and how divergent genomes ...
Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus - Subthalamic Nucleus Network under External Input
(2016)
Hypokinetic symptoms of Parkinson’s disease are usually associated with the excessively strong oscillations and synchrony in the beta frequency band. The origin of this synchronized oscillatory dynamics is being debated. ...
Subcellular fractionation method to study endosomal trafficking of Kaposis sarcoma-associated herpesvirus
(2016)
Background: Virus entry involves multiple steps and is a highly orchestrated process on which successful infection
collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles via ...