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Now showing items 891-900 of 908
Spindle-cell sarcoma of the heart: A rare cause for a cardiac mass
(2012)
Primary cardiac tumors are rare and are usually diagnosed at an advanced stage due to nonspecific symptoms. We report a 46-year-old female who presented to our institution with shortness of breath and was diagnosed with a ...
Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
(2019-07-30)
Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration
phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell
lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ...
Neuroantigen-specific, tolerogenic vaccines: GM-CSF is a fusion partner that facilitates tolerance rather than immunity to dominant self-epitopes of myelin in murine models of experimental autoimmune encephalomyelitis (EAE)
(2011-12-30)
BACKGROUND: Vaccination strategies that elicit antigen-specific tolerance are needed as therapies for autoimmune disease. This study focused on whether cytokine-neuroantigen (NAg) fusion proteins could inhibit disease in ...
Proteome quantification of cotton xylem sap suggests the mechanisms of potassiumdeficiency-induced changes in plant resistance to environmental stresses
(2016-02)
Proteomics was employed to investigate the molecular mechanisms of apoplastic response to potassium(K)-deficiency in cotton. Low K (LK) treatment significantly decreased the K and protein contents of xylem sap. Totally, ...
Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
(2011-08-18)
Multi-walled carbon nanotubes (MWCNTs) are widely used in many disciplines due to their unique physical and chemical properties. Therefore, some concerns about the possible human health and environmental impacts of ...
Metabolic remodeling of human skeletal myocytes by cocultured adipocytes depends on the lipolytic state of the system
(2011-06-20)
Adipocyte infiltration of the musculoskeletal system is well recognized as a hallmark of aging, obesity, and type 2 diabetes. Intermuscular adipocytes might serve as a benign storage site for surplus lipid or play a role ...
Is there a metabolic program in the skeletal muscle of obese individuals?
(2011-04-26)
Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ...
From imitation to innovation: A study of China's drug R&D and relevant national policies
(2011)
Research & Development (R&D) plays an increasingly important role in China's pharmaceutical industry. To gain a competitive edge in the global pharmaceutical market, the current national strategy of China forcefully pushes ...
Pain as a global public health priority
(2011-10-06)
Background
Pain is an enormous problem globally. Estimates suggest that 20% of adults suffer from pain globally and 10% are newly diagnosed with chronic pain each year. Nevertheless, the problem of pain has primarily been ...
In-training practice patterns of combined emergency medicine/internal medicine residents, 2003-2007
(2011-11)
This study seeks to evaluate the practice patterns of current combined emergency medicine/internal medicine (EM/IM) residents during their training and compare them to the typical practice patterns of EM/IM graduates. We ...