Browsing Health Sciences Campus by Title
Now showing items 467-486 of 564
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Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ... -
Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance
(East Carolina University, 2007-08)Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ... -
The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding
(East Carolina University, 2008-02-22)The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ... -
Schedule Distribution and Motor Learning Guided Treatment with Childhood Apraxia of Speech
(East Carolina University, 2011)The purpose of this study was to examine the use of motor learning guided (MLG) treatment with different treatment schedules in the treatment of participants with a diagnosis of childhood apraxia of speech (CAS). Five ... -
Self-contained In-The-Ear device to deliver altered auditory feedback: applications for stuttering
(East Carolina University, 2003)The design and operating characteristics of the first self-contained in-the-ear device to deliver altered auditory feedback is described for applications with those who stutter. The device incorporates a microdigital signal ... -
Self-efficacy in freshman and sophomore nursing students
(East Carolina University, 2012)Healthcare disparities and inequities have been at the forefront of the health agenda, thus supporting that minority healthcare is of poorer quality than that experienced by the majority population. Compounding this issue ... -
Sex, SIN, and Dirty Books
(East Carolina University, 1974-01)The paper discusses various creative approaches used to involve faculty in library operations and to expand service both to faculty and students in an academic health sciences library. Originally published Bulletin of hte ... -
The significance of mirna pathway in peripheral nerve regeneration following sciatic nerve injury.
(East Carolina University, 2012)microRNAs (miRNAs) are small (21-23 nucleotides) single-stranded RNAs that play important roles in post-transcriptional regulation of gene expression. The binding of miRNA to its specific target mRNAs at 3' UTR causes ... -
Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids
(East Carolina University, 2004-04-06)Sinorhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen, both require the bacterial-encoded BacA protein to establish chronic intracellular infections in their respective ... -
Sisserou Talks about Health and Nutrition
(East Carolina University, 2009)This booklet was used in a training program for community health aides in the Commonwealth of Dominica. -
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment
(East Carolina University, 2008-11-03)The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ... -
Smallpox in the Spanish New World
(2009-10-26)Laupus Library History Collections & the Department of Bioethics & Interdisciplinary Studies sponsor the History of Medicine Presentations as an educational service for the East Carolina University community. The Library ... -
Social communication between intellectually disabled, severe middle school students who use augmentative and alternative communication and their typically developing peers
(East Carolina University, 2013)Augmentative and Alternative Communication (AAC) devices are often used as a mode of communication for people who cannot use spoken language to meet all of their communication needs. Current research is limited regarding ... -
Social relatedness disturbances and facial expression recognition deficits in children with reactive attachment disorder
(East Carolina University, 2010)The purpose of this study was to explore and examine the relationship between social relatedness disturbances and facial expression recognition among an outpatient clinic sample (N = 34) of children (aged 6 - 19 years) ... -
Solubility and Bioactivity of the Pseudomonas Quinolone Signal Are Increased by a Pseudomonas aeruginosa-Produced Surfactant
(East Carolina University, 2005-02)Pseudomonas aeruginosa is a gram-negative bacterium that causes serious infections in immunocompromised individuals and cystic fibrosis patients. This opportunistic pathogen controls many of its virulence factors and ... -
Some Cardiomyopathy-Causing Troponin I Mutations Stabilize a Functional Intermediate Actin State
(East Carolina University, 2009-03-18)We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated ... -
Speech in noise ability, outer hair cell function, and working memory for trained flute players.
(East Carolina University, 2015)The process of auditory speech recognition requires verbal ability, working memory, recall, and adequate auditory abilities to recognize speech. There is a well-known positive effect of musical training and experience on ... -
Speech Production Analyses: Characterizing Typical Development versus Childhood Apraxia of Speech
(East Carolina University, 2010)Childhood Apraxia of Speech (CAS) is a controversial diagnosis that is frequently based on clinical perceptions, with treatment success based on the same perceptual measures. Because additional, less abstract diagnostic ...