Now showing items 1-6 of 6

  • Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes 

    Dalrymple, Heidi; Barna, Barbara P.; Malur, Anagha; Malur, Achut G.; Kavuru, Mani S.; Thomassen, Mary Jane (2013)
    Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar ...
  • Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation 

    Barna, Barbara P.; Huizar, Isham; Malur, Anagha; McPeek, Matthew; Marshall, Irene; Jacob, Mark; Dobbs, Larry; Kavuru, Mani S.; Thomassen, Mary Jane (2013-12)
    Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ...
  • Gene-environment interactions in sarcoidosis 

    Culver, Daniel A.; Newman, Lee S.; Kavuru, Mani S. (East Carolina University, 2007-05)
    Susceptibility to most human diseases is polygenic, with complex interactions between functional polymorphisms of single genes governing disease incidence, phenotype, or both. In this context, the contribution of any ...
  • Human antibodies for immunotherapy development generated via a human B cell hybridoma technology 

    Li, Jian; Sai, Tao; Berger, Marc; Chao, Qimin; Davidson, Diane; Deshmukh, Gaurav; Drozdowski, Brian; Ebel, Wolfgang; Harley, Stephen; Henry, Marianne; Jacob, Sara; Kline, Brad; Lazo, Ella; Rotella, Frank; Routhier, Eric; Rudolph, Kathryn; Sage, Jeaneen; Simon, Paul; Yao, Jun; Zhou, Yuhong; Kavuru, Mani S.; Bonfield, Tracey L.; Thomassen, Mary Jane; Sass, Philip M.; Nicolaides, Nicholas C.; Grasso, Luigi (East Carolina University, 2006-03-07)
    Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage ...
  • Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis 

    Malur, Anagha; Kavuru, Mani S.; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane (2012)
    Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP ...
  • Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells 

    Gharib, Sina A.; Malur, Anagha; Huizar, Isham; Barna, Barbara P.; Kavuru, Mani S.; Schnapp, Lynn M.; Thomassen, Mary J. (2016-07-26)
    Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ...