Browsing Health Sciences Campus by Subject "T-Lymphocytes"
Now showing items 1-3 of 3
-
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ... -
NOVEL BIOLOGICS PROMOTE STABLE EXPANSION OF REGULATORY CD25HIGH FOXP3+ T LYMPHOCYTES AS A MEANS FOR AN ADOPTIVE CELL-BASED IMMUNOTHERAPY
(East Carolina University, 2021-06-18)Autoimmune disease arises when a breakdown in immunological self-tolerance causes self-reactive tissue destruction. In Multiple Sclerosis (MS), myelin reactive CD4+ T cells initiate an immune attack on the myelin sheath ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ...