Browsing Brody School of Medicine by Title
Now showing items 7-26 of 27
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Gastrogastric fistulas. A complication of divided gastric bypass surgery.
(East Carolina University, 1995-04)Objective This report warns that gastrogastric fistulas may follow the division of the stomach in bariatric surgery. Summary Background Data Although surgery is the most effective therapy for morbid obesity, the ... -
Gene-environment interactions in sarcoidosis
(East Carolina University, 2007-05)Susceptibility to most human diseases is polygenic, with complex interactions between functional polymorphisms of single genes governing disease incidence, phenotype, or both. In this context, the contribution of any ... -
Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees
(East Carolina University, 1998-12)Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is ... -
Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
(East Carolina University, 2006-03-07)Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage ... -
Identification and Characterization of Optimal Gene Expression Markers for Detection of Breast Cancer Metastasis
(East Carolina University, 2005-08)Sentinel lymph node (SLN) status is highly predictive of overall axillary lymph node involvement in breast cancer. Historically, SLN-positive patients have undergone axillary lymph node dissection in a second ... -
The induction of antigen-specific immunological tolerance and attenuation of inflammation via cytokine antigen fusion protein therapy in a mouse model of pulmonary inflammation
(East Carolina University, 2014)Allergic asthma is a significant medical issue, affecting more than 300 million individuals and causing approximately 250,000 deaths each year. Current asthma therapies temporarily minimize discomfort and manage symptoms, ... -
Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.
(East Carolina University, 1988-04)Insulin-like growth factor-I (IGF-I) in human hepatoma cells (HEP-G2) has, in addition to its effect on cell growth, shortterm metabolic effects acting through its own receptor. We have demonstrated that normal ... -
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
(East Carolina University, 1987-10)We have tested the hypothesis that in vitro exposure of insulin- resistant adipocytes with insulin results in improved insulin action. A primary culture system of adipocytes from obese subjects with ... -
Multicenter Trial of Sentinel Node Biopsy for Breast Cancer Using Both Technetium Sulfur Colloid and Isosulfan Blue Dye
(East Carolina University, 2001-01)Objective To determine the factors associated with false-negative results on sentinel node biopsy and sentinel node localization (identification rate) in patients with breast cancer enrolled in a multicenter ... -
Perforated gastric corpus in a strangulated paraesophageal hernia: a case report
(East Carolina University, 2009-05-07)Introduction: Patients with paraesophageal hernias often present secondary to chronic symptomatology. Infrequently, acute intestinal ischemia and perforation can occur as a consequence of paraesophageal hernias with ... -
Peroxisome Proliferator-Activated Receptor-γ Regulates the Expression of Alveolar Macrophage Macrophage Colony- Stimulating Factor
(East Carolina University, 2008-07-01)Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GMCSF knockout mouse, a murine ... -
Physical Activity Levels of Patients Undergoing Bariatric Surgery in the Longitudinal Assessment of Bariatric Surgery (LABS) Study
(East Carolina University, 2008)Background- Bariatric surgery candidates' physical activity (PA) level may contribute to the variability of weight loss and body composition changes following bariatric surgery. However, there is little research describing ... -
The Ripped Cava
(East Carolina University, 1995-04)Lacerations of the inferior vena cava are associated with a high mortality and may be difficult to repair. The majority of injuries are due to penetrating trauma. Rapid transportation to definitive surgical care with ... -
Robotic Surgical Training in an Academic Institution
(East Carolina University, 2001-10)Objective To detail robotic procedure development and clinical applications for mitral valve, biliary, and gastric reflux operations, and to implement a multispecialty robotic surgery training curriculum for both ... -
Stimulation of glucose uptake by insulin-like growth factor II in human muscle is not mediated by the insulin-like growth factor II/mannose 6-phosphate receptor.
(East Carolina University, 1994-06-15)Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated, especially in skeletal ... -
Thoracic neuroblastoma presenting as a cystic hygroma.
(East Carolina University, 1988-10)A case of thoracic neuroblastoma with extension into the supraclavicular fossa is described. By physical examination and ultrasound the patient was thought to have a cystic hygroma with mediastinal extension. A 'cystic' ... -
Thoracolumbar compression fractures presenting with an acute ileus.
(East Carolina University, 1990-09)Corticosteroids are commonly used in the treatment of connective tissue diseases such as systemic lupus erythematosus. Although they are usually efficacious, osteoporosis leading to spine compression fractures is not ... -
Trends in esophageal cancer and body mass index by race and gender in the state of Michigan
(East Carolina University, 2009-06-23)Background: Adenocarcinoma of the esophagus has been increasing in incidence in the U.S. over the past several decades, particularly among white males. The factors driving the racial disparity in adenocarcinomas rates are ... -
Use of monoamine oxidase and redox enzymes in atrial tissue as novel predictors of postoperative atrial fibrillation
(East Carolina University, 2014)Postoperative atrial fibrillation (POAF) occurs in approximately 30% of cardiac surgery patients. The complication occurs despite advances in surgical procedures. It is associated with increased mortality, morbidity, and ...