Browsing Brody School of Medicine by Author "Akula, Shaw M."
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Cellular miR-150-5p May Have a Crucial Role to Play in the Biology of SARS-CoV-2 Infection by Regulating nsp10 Gene
Akula, Shaw M.; Bolin, Paul; Cook, Paul P. (2022) -
COVID-19 Infection Enhances Susceptibility to OxidativeStress–Induced Parkinsonism
Eells, Jeffrey B.; Akula, Shaw M.; Sriramula, Srinivas; O’Rourke, Dorcas P.; Smeyne, Richard J.; et al (2022-06-09) -
Differential regulation of the attachment of KSHV infected human B cells to ECM by KSHV encoded gB and cellular alpha-V integrins
Dyson, Ossie F.; Oxendine, Telisha L.; Hamden, Khalief E.; Ford, Patrick W.; Akula, Shaw M. (East Carolina University, 2008-07)Kaposi’s sarcoma-associated herpesvirus (KSHV) has two modes replication: latent and lytic replication. Reactivation from latency is dictated, in part, by the cell cycle. Herein, we have attempted to delineate the importance ... -
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
Abrams, Stephen L.; Akula, Shaw M.; Steelman, Linda S.; McCubrey, James A. (2022-02-24) -
FUNCTION OF DISINTEGRIN-LIKE DOMAIN OF KSHV gB IN REGULATING VIRUS INFECTION
Walker, Lia R. (East Carolina University, 2015-12-10)KSHV, also referred to as human herpesvirus-8 (HHV-8), is the eighth and latest identified human herpesvirus. It is the causative agent for a variety of malignancies namely Kaposi’s sarcoma (KS), primary effusion lymphoma ... -
GSK-3β Can Regulate the Sensitivity of MIA-PaCa-2 Pancreatic and MCF-7 Breast Cancer Cells to Chemotherapeutic Drugs, Targeted Therapeutics and Nutraceuticals
Abrams, Stephen L.; Akula, Shaw M.; Meher, Akshaya K.; Steelman, Linda S.; Gizak, Agnieszka; Duda, Przemysław; Rakus, Dariusz; Martelli, Alberto M.; Ratti, Stefano; Cocco, Lucio; Montalto, Giuseppe; Cervello, Melchiorre; Ruvolo, Peter; Libra, Massimo; Falzone, Luca; Candido, Saverio; McCubrey, James A. (2021-04) -
KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
Hussein, Hosni Ahmed Mohamed; Walker, Lia R.; Akula, Shaw M. (2016-02)Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
Hussein, Hosni Ahmed Mohamed (East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection
Hamden, Khalief E.; Ford, Patrick W.; Whitman, Audy G.; Dyson, Ossie F.; Cheng, Shi-Yuan; McCubrey, James A.; Akula, Shaw M. (East Carolina University, 2004-12)Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of ... -
Raman spectroscopy: the gateway into tomorrow's virology
Lambert, Phelps J.; Whitman, Audy G.; Dyson, Ossie F.; Akula, Shaw M. (East Carolina University, 2006-06-28)In the molecular world, researchers act as detectives working hard to unravel the mysteries surrounding cells. One of the researchers' greatest tools in this endeavor has been Raman spectroscopy. Raman spectroscopy is a ... -
Raman tweezers provide the fingerprint of cells supporting the late stages of KSHV reactivation
Dyson, Ossie F.; Ford, Patrick W.; Chen, De; Li, Yong-Qing; Akula, Shaw M. (East Carolina University, 2009-08)Kaposi's sarcoma-associated herpesvirus (KSHV) has both latent and lytic phases of replication. The molecular switch that triggers a reactivation is still unclear. Cells from S phase of cell cycle provide apt conditions ... -
Regulation of KSHV replication by glycoprotein B: chronicles of a virus and its host
Dyson, Ossie F. (East Carolina University, 2011)Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of three cancers: Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and the plasmablastic form of multicentric Castleman disease (MCD), shares many ... -
Resveratrol Inhibits KSHV Reactivation by Lowering the Levels of Cellular EGR-1
Dyson, Ossie F.; Walker, Lia R.; Whitehouse, Adrian; Cook, Paul P.; Akula, Shaw M. (2012)Article Authors Metrics Comments Related Content Abstract Introduction Results Discussion Materials and Methods Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Media ... -
Subcellular fractionation method to study endosomal trafficking of Kaposi’s sarcoma-associated herpesvirus
Walker, Lia R.; Hussein, Hosni Ahmed Mohamed; Akula, Shaw M. (2016-01)Background Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles ... -
Subcellular fractionation method to study endosomal trafficking of Kaposi’s sarcoma-associated herpesvirus
Walker, Lia R.; Hussein, Hosni Ahmed Mohamed; Akula, Shaw M. (2016-01-15)Background: Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles ... -
Wild Type and Gain of Function Mutant TP53 can Regulate the Sensitivity of Pancreatic Cancer Cells to Chemotherapeutic Drugs, EGFR/Ras/Raf/MEK, and PI3K/mTORC1/GSK-3 Pathway Inhibitors, Nutraceuticals and Alter Metabolic Properties
McCubrey, James A.; Meher, Akshaya K.; Akula, Shaw M.; Abrams, Stephen L.; Steelman, Linda S.; LaHair, Michelle M.; Franklin, Richard A.; Martelli, Alberto M.; Ratti, Stefano; Cocco, Lucio; Barbaro, Fulvio; Duda, Przemysław; Gizak, Agnieszka (2022-04-27)