Browsing Brody School of Medicine by Author "Barna, Barbara P."

Now showing items 1-6 of 6

  • Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes 

    Dalrymple, Heidi; Barna, Barbara P.; Malur, Anagha; Malur, Achut G.; Kavuru, Mani S.; Thomassen, Mary Jane (2013)
    Background Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar ...

  • Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation 

    Barna, Barbara P.; Huizar, Isham; Malur, Anagha; McPeek, Matthew; Marshall, Irene; Jacob, Mark; Dobbs, Larry; Kavuru, Mani S.; Thomassen, Mary Jane (2013-12)
    Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ...

  • Review: Carbon Nanotubes and Chronic Granulomatous Disease 

    Barna, Barbara P.; Judson, Marc A.; Thomassen, Mary Jane (2014-06-23)
    Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles ...

  • Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis 

    Malur, Anagha; Kavuru, Mani S.; Marshall, Irene; Barna, Barbara P.; Huizar, Isham; Karnekar, Reema; Thomassen, Mary Jane (2012)
    Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP ...

  • The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation 

    Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher J.; Barna, Barbara P.; Thomassen, Mary Jane (2013)
    BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ...

  • Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells 

    Gharib, Sina A.; Malur, Anagha; Huizar, Isham; Barna, Barbara P.; Kavuru, Mani S.; Schnapp, Lynn M.; Thomassen, Mary J. (2016-07-26)
    Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ...