Browsing Brody School of Medicine by Author "Garcia, Brandon L."
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Borrelia burgdorferi ErpB and ErpQ inhibit C1 complex of the classical pathway of complement through a novel mechanism
Garrigues, Ryan (East Carolina University, 2021-05-03)The complement system is an organized proteolytic cascade of dozens of proteins that functions in the recognition, opsonization, and lysis of pathogenic and altered-host cells. Bloodborne pathogens like the etiologic agent ... -
Borrelia miyamotoi FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions
Booth, Charles E. Jr; Garcia, Brandon L. (2022-05-27) -
DEVELOPMENT OF SMALL-MODELCULE INHIGITORS OF THE INTIATING PROTEASES, C1r AND C1s, OF THE CLASSICAL COMPLEMENT PATHWAY
Rohlik, Denise (2019-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII
Garcia, Brandon L.; Zhang, Ying (2022-07-05) -
Lipoproteome Screening of the Lyme Disease Agent Identifies Inhibitors of Antibody-Mediated Complement Killing
Garrigues, Ryan J.; Garcia, Brandon L.; et al (2022) -
Lyme Disease Pathogenesis
Garcia, Brandon L.; Coburn, Jenifer; Hu, Linden T.; Jewett, Mollie W.; Kraiczy, Peter; Norris, Steven J.; Skare, Jon (2021) -
Outer Surface Lipoproteins from the Lyme Sisease Spirochete Exploit the Molecular Switch Mechanism of the Complement Protease C1s
Garrigues, Ryan J.; Thomas, Sheila; Garcia, Brandon L.; Leong, John M. (2022-09-29) -
A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes
Garrigues, Ryan J.; Garcia, Brandon L.; Pierce, Alexandra D. Powell; Hammel, Michal; Skare, Jon T. (2021-07-04)