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  • Arginase Promotes Neointima Formation in Rat Injured Carotid Arteries 

    Peyton, Kelly J.; Ensenat, Diana; Azam, Mohammed A.; Keswani, Amit N.; Kannan, Sankaranarayanan; Liu, Xiao-Ming; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-04)
    Objective—Arginase stimulates the proliferation of cultured vascular smooth muscle cells (VSMCs); however, the influence of arginase on VSMC growth in vivo is not known. This study investigated the impact of arginase on ...
  • YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells 

    Liu, Xiao-Ming; Peyton, Kelly J.; Mendelev, Natalia N.; Wang, Hong; Tulis, David A.; Durante, William (East Carolina University, 2009-01)
    The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and ...