Browsing Brody School of Medicine by Author "Zauli, Giorgio"
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Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
Simioni, Carolina; Cani, Alice; Martelli, Alberto M.; Zauli, Giorgio; Tabellini, Giovanna; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2014-10)The PI3K/Akt/mTOR signaling cascade is a key regulatory pathway controlling cell growth and survival, and its dysregulation is a reported feature of B-precursor acute lymphoblastic leukemia (B-pre ALL). Torin-2 is a ... -
The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells
Simioni, Carolina; Cani, Alice; Martelli, Alberto M.; Zauli, Giorgio; Alameen, Ayman A.M.; Ultimo, Simona; Tabellini, Giovanna; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2015-07)Hepatocellular carcinoma (HCC) is one of the most common lethal human malignancies worldwide and its advanced status is frequently resistant to conventional chemotherapeutic agents and radiation. We evaluated the cytotoxic ... -
Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia
Cani, Alice; Simioni, Carolina; Martelli, Alberto M.; Zauli, Giorgio; Tabellini, Giovanna; Ultimo, Simona; McCubrey, James A.; Capitani, Silvano; Neri, Luca M. (2015-03)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder in which chemotherapy resistance and refractory relapses occur, with a poorer prognostic outcome. Constitutively active PI3K/Akt/mTOR ...