Now showing items 1-2 of 2

  • Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis 

    Nelson, Nadine; Xiang, Shengyan; Zhang, Xiaohong; Gilvary, Danielle; Djeu, Julie; Husain, Kazim; Malafa, Mokenge; Vohra, Nasreen; Pilon-Thomas, Shari; Ghansah, Tomar (2015-01)
    Background Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression ...
  • Spleen Tyrosine Kinase (Syk) Regulates Systemic Lupus Erythematosus (SLE) T Cell Signaling 

    Grammatikos, Alexandros P.; Ghosh, Debjani; Devlin, Amy; Kyttaris, Vasileios C.; Tsokos, George C. (2013)
    Engagement of the CD3/T cell receptor complex in systemic lupus erythematosus (SLE) T cells involves Syk rather than the zeta-associated protein. Because Syk is being considered as a therapeutic target we asked whether Syk ...