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Brain-derived neurotrophic factor and neurotrophin receptors modulate glutamate-induced phase shifts of the suprachiasmatic nucleus
(East Carolina University, 2006-08)
Light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal ganglion cells. Previous work raised the possibility that brain-derived neurotrophic factor (BDNF) and its high-affinity ...
Mast cells and the IL-33/ST2 axis are essential determinants of carbon nanotube toxicity
(East Carolina University, 2012)
The rise of nanomaterial use in a variety of applications, including biomedical imaging and drug delivery, has led to concern about the potentially hazardous impacts on human health. Mast cells are critical for innate and ...
Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene
(East Carolina University, 2003-12)
Active immunization with fibrillar beta-amyloid peptide (AB42) as well as passive transfer of anti-AB antibodies significantly reduces AB plaque deposition, neuritic dystrophy, and astrogliosis in the brain of mutant amyloid ...
Dopaminergic modulation of the autonomic nervous system: in vitro and in vivo evidence from the mouse
(East Carolina University, 2012)
Central nervous system (CNS) function depends on both the connections between the underlying neurons and neural circuits and their activity. Neuronal activity in turn can be classified as neurotransmission and neuromodulation, ...
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)
The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ...
Fish oil disrupts B cell plasma membrane lateral organization and immunological synapse formation
(East Carolina University, 2012)
Fish oil has immunosuppressive properties that could provide treatment for numerous inflammatory and autoimmune disorders. The primary bioactive components of fish oil, which are the n-3 polyunsaturated fatty acids (PUFAs) ...
THE ROLE OF RETINOIC ACID IN DIRECTING INITIATION OF SPERMATOGENESIS IN THE MOUSE
(East Carolina University, 2015-10-23)
The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis ...
The contribution of motility and chemotaxis in the Borrelia burgdorferi infectious life cycle
(East Carolina University, 2013)
Lyme disease has emerged as an increasing problem for people in the east and northeastern part of the United States. It can cause a chronic debilitating infection if left untreated and is difficult to diagnose. The illness ...
Characterization of FtrABCD: a ferrous iron-specific transporter that is required for the virulence of Brucella abortus 2308 in mice
(East Carolina University, 2016-07-21)
Brucella strains are Gram-negative bacteria that cause abortion and infertility in their natural animal hosts resulting in extensive economic losses. Humans can acquire a chronic, debilitating febrile illness known as ...
Induced ablation of skeletal muscle-specific estrogen receptor-alpha in adult female mice increased the susceptibility to develop skeletal muscle inflammation and glucose intolerance under chronic lipid overload
(East Carolina University, 2018-04-27)
Skeletal muscle-specific ER[alpha] appears to play important roles in regulating skeletal muscle glucose and lipid homeostasis. The overall aim of this dissertation was to determine whether skeletal muscle-specific ER[alpha] ...