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Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.

Nyce, Jonathan W.; Leonard, Sherry Ann; Canupp, Dawn; Schulz, Stefan; Wong, So (East Carolina University, 1993-04-01)

In a model system employing Chinese hamster V-79 cells, the DNA synthesis inhibitor 3'-azido-3'- deoxythymidine (BW A509U, AZT) was shown to induce genome-wide DNA hypermethylation, low-frequency silencing of thymidine ...