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Induced ablation of skeletal muscle-specific estrogen receptor-alpha in adult female mice increased the susceptibility to develop skeletal muscle inflammation and glucose intolerance under chronic lipid overload
(East Carolina University, 2018-04-27)
Skeletal muscle-specific ER[alpha] appears to play important roles in regulating skeletal muscle glucose and lipid homeostasis. The overall aim of this dissertation was to determine whether skeletal muscle-specific ER[alpha] ...
Human T-Cell Leukemia Virus Type I Basic Leucine Zipper Factor (HBZ) Modulates Cellular DNA Damage Repair and Antioxidant Responses to Promote Host Cell Survival and Leukemogenesis
(East Carolina University, 2018-04-19)
Approximately twenty million people worldwide are infected with Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 establishes a life-long, chronic infection which can result in the development of severe HTLV-1 associated ...
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
(East Carolina University, 2018-04-17)
Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ...
INFLUENCE OF PHYSICOCHEMICAL PROPERTIES OF SILVER NANOPARTICLES ON MAST CELL AND MACROPHAGE UPTAKE AND ACTVATION: ROLE OF SCAVENGER RECEPTOR B1
(East Carolina University, 2018-04-09)
Silver nanoparticles (AgNPs) are widely used in consumer products and the medical field for their antimicrobial properties. Some studies reported toxic effects of AgNPs but cellular uptake of AgNPs and AgNP-induced ...
Type. Cast : Edition XI Brody School of Medicine Art & Literary Magazine (2018)
(2018)
An art and literary magazine published by the Brody School of Medicine, Division of Health Sciences. The magazine contains artwork and writings by Brody School of Medicine's medical students and others throughout the Health ...
Impact of prostate cancer treatment on pelvic nerve injury and erectile function
(East Carolina University, 2018-07-17)
Following prostate cancer treatment, many men will experience urogenital side effects including erectile dysfunction (ED), a condition significantly affecting survivor quality of life. The cause of ED after treatment is ...
Embracing a plant-based diet. What is it and what's the evidence
(2017-05)
In this paper we present a case of a young health professional feeling peer pressure to become vegan. We also present a case of a vegan baby. We discuss nutrient of concerns for individuals restricting or eliminating animal ...
Factors Affecting Patient Portal Use Among Low-Income Pregnant Women: Mixed-Methods Pilot Study
(2018-03)
Background: Patient portals offer patients personalized and secure Web access to their medical information and enable patients to manage their health care online. However, there is a lack of information about patient ...
Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review
(2018-03-21)
Background: Healthcare-acquired hypernatremia (serum sodium >145 mEq/dL) is common among critically ill and other
hospitalized patients and is usually treated with hypotonic fluid and/or diuretics to correct a “free water ...
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)
Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ...