Browsing Open Access by Subject "MCL-1; ABT-737; BH3 mimetic; AML; ERK; apoptosis"
Now showing items 1-1 of 1
-
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex
(2012-04)Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members using BH3-mimetic drugs such as ABT-737. Though effective against BCL2 and [BCL-X.sub.L], ...