Browsing Biochemistry and Molecular Biology by Author "Keiper, Brett D."
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Cap-Independent Translation Promotes Germ Cell Apoptosis through Apaf-1/CED-4 in a Caspase-Dependent Mechanism
Contreras, Vince; Friday, Andrew J.; Morrison, J. Kaitlin; Hao, Enhui; Keiper, Brett D. (2011) -
A germline-specific isoform of eIF4E (IFE-1) is required for efficient translation of stored mRNAs and maturation of both oocytes and sperm
Henderson, Melissa Anne; Cronland, Elizabeth; Dunkelbarger, Steve; Contreras, Vince; Strome, Susan; Keiper, Brett D. (East Carolina University, 2009-05-15)Fertility and embryonic viability are measures of efficient germ cell growth and development. During oogenesis and spermatogenesis, new proteins are required for both mitotic expansion and differentiation. Qualitative and ... -
Induction of cap-independent BiP () and Bcl-2 () translation in response to eIF4G (IFG-1) depletion in
Morrison, J. Kaitlin; Friday, Andrew J.; Henderson, Melissa Anne; Hao, Enhui; Keiper, Brett D. (2014-04) -
The involvement of cap-independent mRNA translation in cell fate decisions
Morrison, J. Kaitlin (East Carolina University, 2014)During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism. One specific example of ... -
Multiple Translation Factor eIF4G (IFG-1) Isoforms are Required for the Apoptosome-Dependent Activation of Germ Cell Apoptosis
Contreras, Vince (East Carolina University, 2010)Apoptosis is a naturally occurring process during animal development required for the programmed killing and removal of injured cells. Cellular insult induces a switch in translation that allows for the rapid synthesis ... -
Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity
Friday, Andrew J.; Keiper, Brett D. (2015) -
Protein synthesis regulation in the germ line affects gamete differentiation
Subash, Jacob (2013-05) -
Selective Recruitment of Germ Cell mRNAs by eIF4 Factors
Friday, Andrew J. (East Carolina University, 1/13/16)During germ line development critical steps in the proliferation and differentiation of stem cells into oocytes and sperm are regulated by mRNA translational control. This regulation changes the subset of proteins being ... -
The unique roles of IFE-1, a germline-specific isoform of eukaryotic translation factor 4E, during gametogenesis
Henderson, Melissa Anne (East Carolina University, 2009)Fertility and embryonic viability are measures of efficient germ cell growth and differentiation. During oogenesis, spermatogenesis and embryogenesis cells initially proliferate then differentiate into specific tissues. ...