Browsing Internal Medicine by Author "McPeek, Matthew"
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The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
Huizar, Isham; Malur, Anagha; Patel, Janki; McPeek, Matthew; Dobbs, Larry; Wingard, Christopher J.; Barna, Barbara P.; Thomassen, Mary Jane (2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
The M2a macrophage phenotype accompanies pulmonary granuloma resolution in Mmp12 knock-out mice instilled with multiwall carbon nanotubes
Ogburn, David; Bhalla, Sophia; Leffler, Nan; Mohan, Arjun; Malur, Anagha; Malur, Achut G.; McPeek, Matthew; Barna, Barbara P.; Thomassen, Mary Jane (MDPI, 2021-10-13)Sarcoidosis is a chronic disease with unknown etiology and pathophysiology, characterized by granuloma formation. Matrix Metalloproteinase-12 (MMP12) is an elastase implicated in active granulomatous sarcoidosis. Previously, ...