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A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
(2015-06-17)
Background
Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral ...
Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance.
(East Carolina University, 1993-04-01)
In a model system employing Chinese hamster V-79 cells, the DNA synthesis inhibitor 3'-azido-3'- deoxythymidine (BW A509U, AZT) was shown to induce genome-wide DNA hypermethylation, low-frequency silencing of thymidine ...
American Ginseng Modifies 137Cs-Induced DNA Damage and Oxidative Stress in Human Lymphocytes
(East Carolina University, 2009-01-01)
The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content. Since the key mechanism of radiation-induced cell death and tissue ...
Pembrolizumab Induced Tumor Shrinkage in Rare Osseous Metastasis of Basal Cell Carcinoma
(2023-07-31)
Cutaneous basal cell carcinoma (BCC) is an
increasingly common malignancy with a rising
incidence over the past decade. 1 BCC seldom
exhibits lymphatic or hematogenous metastasis with
an incidence of only 0.0028% ...
Reducing Neurocognitive Impairment In Treating Limited Stage Small Cell Lung Cancer with Gamma Knife Radiosurgery
(2023-07-31)
Small Cell Lung Cancer (SCLC) represents 15% of lung cancer and is characterized by rapid growth with metastasis resulting in poor survival rates.1 SCLC with a limited stage defined as disease limited to the hemithorax ...