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Fast acting SNARE-cleaving enzymes
(2015-10-06)
The present invention relates to metalloprotease enzymes isolated from scorpion venom, their nucleic acid and amino acid sequences, and methods of use thereof in the treatment of various diseases, disorders and cosmetic ...
Fast acting SNARE-cleaving enzymes
(2015-10-06)
The present invention relates to metalloprotease enzymes isolated from scorpion venom, their nucleic acid and amino acid sequences, and methods of use thereof in the treatment of various diseases, disorders and cosmetic ...
J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
(2017-09-08)
Provided is a method of preventing and/or treating a skin disorder and/or an oral disorder including administering to a subject in need thereof an effective amount of a compound of formula (I) or a prodrug or derivative ...
EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy
(2016-03)
Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological, and neuropathological features of 50 children ...
Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation
(2014-06)
Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome. The pre-programmed fate of the X-chromosomes is thought ...
HIV Screening and Awareness Survey for Pregnant Women in a Remote Area in Xinjiang Uyghur Autonomous Region of China
(2011-11)
Objective:
The number of people infected with human immunodeficiency virus (HIV) in China has increased in recent years. HIV screening for pregnant women was performed in a remote area in Xinjiang, as an effort to promote ...
Effects of robotic-assisted laparoscopic prostatectomy on surgical pathology specimens
(2012)
Background
Robotic-assisted laparoscopic prostatectomy (RALP) has greatly changed clinical management of prostate cancer. It is important for pathologists and urologists to compare RALP with conventional open radical ...
VZV in biopsy-positive and -negative giant cell arteritis: Analysis of 100+ temporal arteries
(2016-03)
Objective:
Varicella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA).
Methods:
Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies ...
Histological and immunohistochemical features of the spleen in persistent polyclonal B-cell lymphocytosis closely mimic splenic B-cell lymphoma
(2012)
Persistent polyclonal B-cell lymphocytosis (PPBL) is rare and intriguing hematological disorder predominantly reported in young to middle- aged smoking women. It is characterized by persistent moderate polyclonal B-cell ...
Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia?
(2012)
Background
Anterior mediastinal masses are a rare but well documented finding in Graves disease. The vast majority of these lesions represents benign thymic hypertrophy and regress after treatment of the hyperthyroidism. ...