Browsing Pharmacology and Toxicology by Author "McMillen, Brian A."
-
Interaction of memantine with ethanol consumption and dopaminergic function in high ethanol preferring rats
Malpass, Gloria Elaine (East Carolina University, 2009)N-methyl-D-aspartate (NMDA) receptor antagonists have been reported to decrease ethanol consumption in rodents, but these drugs often produce adverse side effects. Memantine is a neuroprotective and low-affinity, ... -
Interactions of a Dopamine D Receptor Agonist with Glutamate NMDA Receptor Antagonists on the Volitional Consumption of Ethanol by the mHEP Rat
McMillen, Brian A.; Lommatzsch, Courtney L.; Sayonh, Michael J.; Williams, Helen L. (2013-03)Stimulation of the dopamine D1 receptor is reported to cause the phosphorylation of DARPP-32 at the thre34 position and activates the protein. If intracellular Ca2+ is increased, such as after activation of the glutamate ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
Nagchowdhuri, Partha S. (East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ...