Browsing Pharmacology and Toxicology by Author "Robidoux, Jacques"
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Catecholamine metabolism via monoamine oxidase (MAO) within myocardium of individuals with type 2 diabetes
Nelson, Margaret A. M. (East Carolina University, 2019-04-23)The primary comorbidity and cause of mortality in type 2 diabetes is cardiovascular disease. The structural and the functional cardiac remodeling observed in patients with type 2 diabetes has been shown to be driven by a ... -
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
Rogers, Artie Carlyle (East Carolina University, 2013)Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ... -
EXPLORING DIFFERENCES IN INDIVIDUAL SUSCEPTIBILITY TO LIPOTOXICITY AND THE UNDERLYING MECHANISMS IN THE MITOCHONDRIA OF PRIMARY PREADIPOCYTES
Shine, Jared M (East Carolina University, 2018-07-17)Prolonged exposure to fatty acids (FAs), at levels normally seen during fasting, can be cytotoxic in vulnerable cells including preadipocytes. Prior work from our laboratory has shown that FAs cause mitochondrial inner ...