Browsing Pharmacology and Toxicology by Author "Soderstrom, Ken"
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Cannabinoid exposure during zebra finch sensorimotor vocal learning persistently alters expression of endocannabinoid signaling elements and acute agonist responsiveness
Soderstrom, Ken; Poklis, Justin L; Lichtman, Aron H (2011)Background Previously we have found that cannabinoid treatment of zebra finches during sensorimotor stages of vocal development alters song patterns produced in adulthood. Such persistently altered behavior must be ... -
CB1 Antagonism Increases Excitatory Synaptogenesis in a Cortical Spheroid Model of Fetal Brain Development
Papariello, Alexis; Taylor, David; Soderstrom, Ken; Litwa, Karen (2021) -
EFFECTS OF CANNABIDIOL ON VOCAL LEARNING AND RECOVERY FROM CNS DAMAGE
Alalawi, Ali Mohammed (East Carolina University, 2019-06-19)Cannabidiol (CBD), a non-euphorigenic compound derived from Cannabis, shows promise for improving recovery following cerebral ischemia and was recently effective for the treatment of childhood seizures caused by Dravet and ... -
Effects of psychological stressors and [delta]⁹-THC acutely and chronically on zebra finch song behavior and dendritic spine density
Holland, Tessa Lynn (East Carolina University, 2020-06-22)This dissertation investigated song performance and dendritic spine density, following acute restraint stress in adult zebra finches and, following chronic mild stress and CB1 receptor partial agonist [delta]⁹-tetrahydrocannabinol ... -
OPPOSING PERSISTENT BEHAVIORAL EFFECTS OF PHYTO- AND ENDOCANNABINOIDS FOLLOWING CHRONIC DEVELOPMENTAL, BUT NOT ADULT, TREATMENTS
Aldhafiri, Ahmed Jaleel (East Carolina University, 2019-04-23)The rate of adolescent Cannabis abuse is increasing for recreational purposes and it is thought to be linked to a range of developmental and social problems. Many studies have demonstrated effects of early Cannabis exposure ... -
Oxytocin Modulation of Zebra Finch Vocal Development
Riffle, Brandy W. (East Carolina University, 2010)Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling ... -
Software for objective comparison of vocal acoustic features over weeks of audio recording: KLFromRecordingDays
Soderstrom, Ken; Alalawi, Ali Mohammed (2017-10-09)KLFromRecordingDays allows measurement of Kullback–Leibler (KL) distances between 2D probability distributions of vocal acoustic features. Greater KL distance measures reflect increased phonological divergence across the ...