Now showing items 1-3 of 3

  • Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains 

    Baulac, Stephanie; Lu, Hope; Strahle, Jennifer; Yang, Ting; Goldberg, Matthew S.; Shen, Jie; Schlossmacher; Lemere, Cynthia A.; Lu, Qun; Xia, Weiming (East Carolina University, 2009-02-25)
    Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ...
  • Presenilin-1 inhibits delta-catenin-induced cellular branching and promotes delta-catenin processing and turnover 

    Kim, Jin-Sook; Bareiss, Sonja; Kim, Kyung Keun; Tatum, Rodney; Han, Jeong-Ran; Jin, Yun Hye; Kim, Hangun; Lu, Qun; Kim, Kwonseop (East Carolina University, 2006-12-29)
    Although delta-catenin/neural plakophilin-related armadillo protein (NPRAP) was reported to interact with presenilin-1 (PS-1), the effects of PS-1 on delta-catenin have not been established. In this study, we report that ...
  • Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment 

    Yang, Tao; Knowles, Juliet K.; Lu, Qun; Zhang, Hong; Arancio, Ottavio; Moore, Laura A.; Chang, Timothy; Wang, Qian; Andreasson, Katrin; Rajadas, Jayakumar; Fuller, Gerald G.; Xie, Youmei; Massa, Stephen M.; Longo, Frank M. (East Carolina University, 2008-11-03)
    The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ...