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Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
(2013)
Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ...
Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
(2015-04)
Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme ...
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
(5/16/2016)
Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ...
Smoking and dietary inadequacy among Inuvialuit women of child bearing age in the Northwest Territories, Canada
(2013)
Objective
The prevalence of smoking in Aboriginal Canadians is higher than non-Aboriginal Canadians, a behavior that also tends to alter dietary patterns. Compared with the general Canadian population, maternal smoking ...