Mitchell, James E.King, Wendy C.Chen, Jia-YuhDevlin, Michael J.Flum, DavidGarcia, LuisPender, John R.Kalarchian, Melissa A.Khandelwal, SaurabhMarcus, Marsha D.Schrope, BethStrain, GladysWolfe, BruceYanovski, Susan2016-07-282016-07-282014-05Obesity (Silver Spring, Md.); 22:8 p. 1799-18061930-7381http://hdl.handle.net/10342/5854Objective To examine changes in depressive symptoms and treatment in the first three years following bariatric surgery. Design and Methods The Longitudinal Assessment of Bariatric Surgery-2 is an observational cohort study of adults (n=2,458) who underwent a bariatric surgical procedure at one of ten US hospitals between 2006–9. This study includes 2,148 participants who completed the Beck Depression Inventory (BDI) at baseline and ≥ one follow-up visit in years 1–3. Results At baseline, 40.4% self-reported treatment for depression. At least mild depressive symptoms (BDI score≥10) were reported by 28.3%; moderate (BDI score 19–29) and severe (BDI score ≥30) symptoms were uncommon (4.2% and 0.5%, respectively). Mild-to-severe depressive symptoms independently increased the odds (OR=1.75; p=.03) of a major adverse event within 30 days of surgery. Compared with baseline, symptom severity was significantly lower at all follow-up time points (e.g., mild-to-severe symptomatology was 8.9%, 6 months; 8.4%, 1yr; 12.2%, 2yrs; 15.6%, 3yrs; ps<.001), but increased between 1 and 3 years postoperatively (p<.01). Change in depressive symptoms was significantly related to change in body mass index (r=.42; p<0001). Conclusion Bariatric surgery has a positive impact on depressive features. However, data suggest some deterioration in improvement after the first postoperative year.Roux-en-Y gastric bypasslaparoscopic adjustable gastric bandsevere obesityweight losstreatmentdepressionantidepressant medicationArticlepmc411502610.1002/oby.20738