Antar, Marwa2023-06-052023-06-052023-052023-05-03May 2023http://hdl.handle.net/10342/12852Sleep plays a vital role in learning and memory consolidation. Several studies used brain models of sleep deprivation (SD) and insomnia to study the association between sleep deficiency and cognitive decline conditions. SD was found to cause similar, albeit subtle, cognitive decline symptoms displayed by dementia patients affecting attentional functions, decision making, working and long-term memory. This study examines the effect of sleep restriction (SR) on brain networks and utilizes Functional Connectivity (FC) analysis to identify patterns of information processing between different brain regions. It particularly applies weighted phase-lag index (wPLI) to quantify brain signals synchronization levels during a visual oddball paradigm task that evokes event-related potentials (ERPs) associated with face recognition. This study also examines the viability of graph theoretic analysis (GTA), which provides a holistic view on the brain network topology. GTA quantifies the brain connectivity features to assess the global efficiency and local efficiency of information processing, pre- and post- SR intervention. Significant alterations were found in all graph indices mainly in α-, µ- and β- frequency bands due to induced mental fatigue. The obtained results reveal significantly lower local connections (p < 0.05) and lower global efficiency (p < 0.001), particularly in the α- band as a result of mental fatigue, reflecting the impact of sleep loss on attention and memory processing.application/pdfenFunctional connectivityGraph theorynetwork analysissleep deprivationsleep restrictioncognitive declinebrain networkevent-related potentialelectroencephalogramMaster's Thesis2023-06-02