Gonzales, MiaPipalia, AmrishWeil, Andrew2020-04-212020-04-212019-04-02http://hdl.handle.net/10342/8296Heparin-induced thrombocytopenia (HIT) type II is caused by antibody production that bind complexes between heparin and platelet factor 4 leading to platelet consumption and thrombosis. In a small subset of cases referred to as autoimmune HIT, the antibodies activate platelets even in the absence of heparin. Refractory HIT is a type of autoimmune HIT in which thrombocytopenia persists for weeks after heparin discontinuation and carries increased risk for thrombosis and more severe thrombocytopenia. We present a case of refractory HIT with cerebral venous sinus thrombosis (CVST) that was successfully treated with a change in anticoagulant alongside steroids and a second trial of intravenous immunoglobulin (IVIg).heparin-induced thrombocytopenia, cerebral venous sinus thrombosis, IVIg, refractory HIT, autoimmune HITArticle10.1177/2324709619832324