Busija, David W.Bari, FerencDomoki, FerencLouis, Thomas2011-02-172011-05-172011-02-172011-05-172007-11Brain Research Reviews; 56:1 p. 89-100http://hdl.handle.net/10342/3234Glutamate and its synthetic analogues N-methyl-D-aspartate (NMDA), kainate, and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) are potent dilator agents in the cerebral circulation. The close linkage between neural activity-based release and actions of glutamate on neurons and the related decrease in cerebral vascular resistance is a classic example in support of the concept of tight coupling between increased neural activity and cerebral blood flow. However, mechanisms involved in promoting cerebral vasodilator responses to glutamatergic agents are controversial. Here we review the development and current status of this important field of research especially in respect to cerebrovascular responses to NMDA receptor activation. Originally published Brain Research Review, Vol. 56, No. 1, Nov 2007en-USAuthor notified of opt-out rights by Cammie Jennings prior to upload of this article.GlutamateCerebral circulationCerebral arteriesNitric OxideNeuronsIschemiaN-methyl-D-aspartate receptorsRatsRabbitsPigletsArticlePMC217415410.1016/j.brainresrev.2007.05.011