Johnson, Jordan M.Verkerke, Anthony R.P.Maschek, J. AlanFerrara, Patrick J.Lin, Chien-TeKew, Kimberly A.Neufer, P. DarrellLodhi, Irfan J.Cox, James E.Funai, Katsuhiko2020-04-212020-04-212019-11-08http://hdl.handle.net/10342/8309Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking PEMT (PEMTKO) are cold-intolerant when fed a high-fat diet (HFD) due to unclear mechanisms. The purpose of this study was to determine whether PEMT-derived phospholipids are important for the function of uncoupling protein 1 (UCP1) and thus for maintenance of core temperature.Article10.1016/j.molmet.2019.10.007