Gordon, Scott EdwardLake, Jordan A.Westerkamp, Christopher M.Thomson, David M.2010-11-172011-05-162010-11-172011-05-162008-10Exercise and Sports Sciences Reviews; 36:4 p. 179-186http://hdl.handle.net/10342/3009The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we provide evidence to support the hypothesis that elevated 5'-adenosine monophosphate–activated protein kinase activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle. Originally published in Exercise and Sports Sciences Reviews 2008 Vol. 36, No. 4.en-USAuthor notified of opt-out rights by Kent Nixon Myers prior to upload of this article.SarcopeniaAgingLoadingHypertrophyFiber typeTranslationProtein synthesisArticlePMC265941310.1097/JES.0b013e3181877e13