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Now showing items 9020-9039 of 10620
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Targeting Exportin-1 to Inhibit HTLV-1 Infection
(East Carolina University, 8/5/2020)Human T-cell Leukemia Virus Type-1 (HTLV-1) is a complex human retrovirus that infects around 20 million people globally. Transmission of this retrovirus occurs by sexual intercourse, contaminated blood, and from mother ... -
Targeting Kremen1 Downregulation with RVG-9R/siRNA Complexes in the Triple-Transgenic Mouse Model of Alzheimer’s Disease
(East Carolina University, 2017-07-19)Alzheimer's disease (AD) is a progressive disease characterized by cognitive decline and memory loss. Memory loss observed in AD results from the loss of neurons and synapses which may be caused by the disruption of the ... -
Targeting prostate cancer based on signal transduction and cell cycle pathways
(East Carolina University, 2008-06-15)Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, ... -
Targeting Psychological Flexibility in Youth to Enhance Health-Related Behaviors
(East Carolina University, 2019-07-22)Background: Adolescents are uniquely vulnerable to a wide range of psychological issues and often, concerns inadequately addressed. When addressed, mental health concerns are commonly handled in schools, which are uniquely ... -
Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
(2017-08-24)A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative ... -
Targeting the initiating proteases of the complement system using structure-based small molecule drug discovery
(East Carolina University, 2023-07-21)The complement system is an essential element of host development and immune homeostasis. This immunoregulatory enzyme cascade is driven by serine protease activation and plays critical roles in the recognition of danger ... -
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
(East Carolina University, 2009-01)Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological properties have been elucidated, including their distinct replicative properties, cell surface phenotypes, their ... -
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ... -
Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance
(East Carolina University, 2007) -
Task Specific Effects of Unilateral Eccentric and Concentric Exercise on Spinal Excitability of the Contralateral Homologous Plantar Flexors.
(East Carolina University, 2011)It is well established that resistance training increases the size and strength of the trained muscles. It is also known that unilateral muscle contractions can produce strength gains in the non-exercised contralateral ... -
A Taste of Culture : Perceptions About American Fast Food in China
(East Carolina University, 2012)This exploratory study examined perceptions about American fast food among urban, Beijing residents to explore three major objectives; perceptions about taste preferences and nutrition value, the eating relationships of ... -
Teach, Assess, and Redesign: Creating a Framework of Universal Design for Students with Learning Disabilties
(2013-04-12)At the main library of a public, four year university, we are collaborating with an innovative campus program to improve our information literacy services for students with multiple learning disabilities. The poster session ... -
TEACHER AS RESEARCHER: A CASE STUDY ON MULTIMODAL COMMUNICATION INTERVENTION IN THE SPECIAL EDUCATION CLASSROOM
(2014)Functional communication has always been a challenge for individuals with severe intellectual disabilities and speech and language impairments, yet it is one of the most important aspects of our daily life as humans. It ... -
TEACHER EVALUATION IN NORTH CAROLINA : TEACHER PERCEPTIONS DURING A TIME OF CHANGE
(East Carolina University, 2011)Teacher evaluation has the potential to lead to improved instruction and professional growth, but, in practice, this potential is often unrealized. North Carolina has revised its teacher evaluation process to include many ...