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Now showing items 2656-2675 of 5334
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Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
(2013-05)Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7DNp53) ... -
Inhibition of Cdk2 kinase activity selectively targets the CD44/CD24 stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells
(2014-09)Inflammatory breast cancer (IBC) is an angioinvasive and most aggressive type of advanced breast cancer characterized by rapid proliferation, chemoresistance, early metastatic development and poor prognosis. IBC tumors ... -
The inhibition of CHO-K1-BH4 cell proliferation and induction of chromosomal aberrations by brevetoxins in vitro
(East Carolina University, 2006-07)Brevetoxins (PbTxs) are highly potent trans-syn polyether neurotoxins produced during blooms of several species of marine dinoflagellates, most notably Karenia brevis. These neurotoxins act on voltage-sensitive sodium ... -
Inhibition of contraction and myosin light chain phosphorylation in guinea-pig smooth muscle by p21-activated kinase 1
(East Carolina University, 2003-06-01)The p21-activated protein kinases (PAKs) have been implicated in cytoskeletal rearrangements and modulation of non-muscle contractility. Little, however, is known about the role of the PAK family members in smooth muscle ... -
Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
(2014)We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase ... -
Inhibition of Nischarin Expression Attenuates Rilmenidine-Evoked Hypotension and Phosphorylated Extracellular Signal-Regulated Kinase 1/2 Production in the Rostral Ventrolateral Medulla of Rats
(East Carolina University, 2008-01)Imidazoline (I1)-evoked hypotension is linked to enhanced phosphorylated extracellular signalregulated kinase (pERK)1/2 production in the rostral ventrolateral medulla (RVLM). Recent cell culture findings suggest that ... -
Inhibition of Quorum Sensing by a Pseudomonas aeruginosa dksA Homologue
(East Carolina University, 2001-03)The Pseudomonas aeruginosa las (lasR-lasI) and rhl (rhlR-rhlI) quorum-sensing systems regulate the expression of several virulence factors, including elastase and rhamnolipid. P. aeruginosa strain PR1-E4 is a lasR deletion ... -
Inhibition of Stuttering from Second Speech Signals: An Evaluation of Temporal and Hierarchical Aspects
(East Carolina University, 2012)Stuttering is an intermittent and involuntary speech disorder overtly characterized by syllable repetitions, phoneme prolongations and postural fixations that disrupt the natural flow of speech. Overt stuttering is reduced ... -
Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase
(2012-10)Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ... -
Inhibition of vascular smooth muscle growth via signaling crosstalk between amp-activated protein kinase and camp-dependent protein kinase
(2012-10-29)Abnormal vascular smooth muscle (VSM) growth is central in the pathophysiology of vascular disease yet fully effective therapies to curb this growth are lacking. Recent findings from our lab and others support growth control ... -
Inhibitory and oxidative effects of gossypol on MCF7 Breast Cancer cells in vitro
(East Carolina University, 2013)Human cancer is the second leading cause of death in the United States and breast cancer is responsible for the second highest number of deaths in women with cancer worldwide. Today, cancer is becoming more and more ... -
Iniquities
(East Carolina University, 2015)This thesis is a representative collection of short stories that I have written as part of my Master's requirements. The four pieces included demonstrate the overarching style, length, and major themes of much of my recent ... -
Initial Characterization of the FlgE Hook High Molecular Weight Complex of
(2014)The spirochete periplasmic flagellum has many unique attributes. One unusual characteristic is the flagellar hook. This structure serves as a universal joint coupling rotation of the membrane-bound motor to the flagellar ... -
Initiating Practice Guidelines for Postpartum Depression Screening at Well-Child Visits
(2014-11-21)Purpose: This project examined the process of initiating postpartum depression (PPD) screening via a PPD protocol at 2 month well-child visit in four pediatric/family practice offices in a rural North Carolina county. The ... -
Inner Change : The Artist and Self-Actualization
(East Carolina University, 2010)This report is written in support of the thesis exhibition entitled "Inner Change", which investigates the idea of self-actualization through the use of self-portraits juxtaposed with personal imagery to represent my ... -
Innovations in Health Sciences Librarianship
(2013-11)A presentation on innovations in the delivery of library services for students and faculty in the health sciences. -
INNOVATIONS IN HIGHER EDUCATION CLINICAL INSTRUCTOR TRAINING FOR OCCUPATIONAL THERAPY: A Program Evaluation
(East Carolina University, 2020-01-07)The purpose of this study is to evaluate a clinical instructor program model by using a program evaluation research design to determine best practices for an open access clinical instructor training program. Evaluating the ... -
Innovative Controller Design for a 5MW Wind Turbine Blade
(2018-06-29)The development and evaluation of a nonlinear pitch controller for wind turbine blades and the design and modeling of an associated actuator and controller was examined. The pitch actuator and controller were modeled and ... -
Inpatient Management of Acute Hypertension
(2015-12-01)Abstract One of every 4 patients admitted to U.S hospitals has hypertension. Few hypertension guidelines address the management of inpatient hypertension. The body of evidence suggests that management of hypertension ... -
Inquiry: A Pedagogy for Personal Empowerment, Collaboration, and Democracy
(East Carolina University, 2019-11-27)Purpose: Inquiry-based pedagogy is rare within the educational landscape. It is even more rare for students who face multiple challenges to success, including racism and poverty. Inquiry- based pedagogy substantially ...