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Now showing items 2487-2506 of 10618
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DEVELOPMENT OF SMALL-MODELCULE INHIGITORS OF THE INTIATING PROTEASES, C1r AND C1s, OF THE CLASSICAL COMPLEMENT PATHWAY
(2019-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
Development of small-molecule inhibitors of the initiating proteases, C1r and C1s, of the classical complement pathway
(East Carolina University, 2019-12-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
Development of the ECU Behavioral and Lifestyle Risk Factor Assessment in Cardiology
(East Carolina University, 2021-12-08)Background: Atrial fibrillation (AF) occurs when rapid and disorganized electrical signals cause the atria in the heart to irregularly beat, not allowing blood to effectively flow from the atria to the ventricles. Over ... -
Development of the Peripartum Cardiomyopathy Quality Of Life Registry
(East Carolina University, 2016-07-08)Peripartum cardiomyopathy (PPCM) is a relatively rare form of heart failure that develops in young women in the third trimester of pregnancy or during the postpartum period. Despite its potentially devastating impact on ... -
Development of the Special Olympics North Carolina MedFest Toolkit
(2020-04-19)[BACKGROUND] Limited access to quality healthcare for individuals living with an intellectual disability (ILID) has numerous implications, including poorer health outcomes and significant health disparities for the ... -
DEVELOPMENT OF UNNATURAL SUBSTRATES AND TRYPTOPHAN AMINO ACIDS TO STUDY PROTON COUPLED ELECTRON TRANSFER IN ENZYMES
(East Carolina University, 2020-12-09)Proton-coupled electron transfer plays an important role in substrate oxidation by C-H bond cleavage and long-range pathways associated with bioenergetics. This thesis is focused on the synthesis of unnatural substrates ... -
Development of Walk Tests to Estimate Aerobic Fitness in 10 to 13 Year-Old Children
(East Carolina University, 2013)Aerobic fitness is an important indicator of health for children. Estimation of aerobic fitness (VO₂[subscript]max) from field-based tests is an essential aspect of youth fitness tests. Field tests can also provide researchers ... -
Developmental Implications of Youth Sport Participation on Physical Activity and Sport Participation in Young Adulthood
(East Carolina University, 2017-12-14)This study sought to address a point of controversy within youth sports: whether young athletes should specialize early (e.g., Ericsson, Krampe & Tesch-Römer, 1993) or if it is favorable to follow the path of early ... -
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ... -
Developmental pathway alterations in the stress axis of chickens exposed in ovo to an emerging environmental contaminant
(East Carolina University, 2016-12-13)Pharmaceutical and personal care products are present in the natural environment by way of the wastewater stream. They are persistent in the environment and have bioaccumulative abilities that threaten the health of both ... -
Developmental Patterns of Cleistogamy and Chasmogamy in Triodanis perfoliata
(2015-05)Some plants exhibit mixed mating, in which individual plants utilize both cross and self-fertilization. Dimorphic cleistogamy is one form of mixed mating. In plants that display dimorphic cleistogamy, both chasmogamous ... -
The Devonian West Falls Formation, implications of sedimentation controlled by preexisting structures, West Virginia
(East Carolina University, 2012)The Devonian (Frasnian) aged West Falls Formation in West Virginia contains gamma-ray signatures that have been interpreted to indicate sedimentation within a foreland (foredeep) basin. The West Falls Formation includes ... -
Diabetes Education in Rural Appalachia
(2010-10-28)Introduction: Diabetes education has long been a problem at rural health sites like Tug River Health Association at Gary, WV. Many providers expressed a need of handouts on diabetic topics that are both informative and ...