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Now showing items 974-993 of 6589
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Claudin-7 increases chemosensitivity to cisplatin in human NCI-H522 lung cancer cells
(East Carolina University, 2010)Lung cancer is a leading cause of cancer death for both men and women worldwide. The 5-year survival rate for lung cancer is only 15%, and it accounts for approximately 1.4 million deaths every year. Recently, it has ... -
Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
(2019-07-30)Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ... -
Claudins in intestines
(2013-07) -
Claudin‑7 modulates cell‑matrix adhesion that controls cell migration, invasion and attachment of human HCC827 lung cancer cells
(2018-12-31)Claudins are a family of tight junction proteins, and serve important roles in epithelial barrier, selective ion transports and cancer metastasis. Although the exact role of claudin-7 in human lung cancer has not been ... -
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
(East Carolina University, 2011)In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ... -
Climate Change Alters Trophic Interactions in Coastal Ecosystems
(East Carolina University, 2016-05-04)Understanding the effects of multiple anthropogenic changes on local ecosystems is important for understanding community interactions. Because they lie at the interface between the land and sea coastal ecosystems are often ... -
Climate Change and the Sea Breeze in the North Carolina Coast
(East Carolina University, 2016-07-25)Forecasting SB genesis and evolution is often a difficult task for coastal meteorologists. This is especially the case when attempting to forecast SB-induced precipitation, as not every SB front induces rainfall. The two ... -
Climate change effects on precipitation organization : a summertime case study in the southeast United States
(East Carolina University, 2016-08-18)The delivery of precipitation through large and small scale precipitation features plays a key role in the hydrological cycle. Therefore, it is important to understand how the organization of precipitation will change as ... -
A Climatology of the Structure, Frequency, and Propagation of Midlatitude Cyclones that Affect North Carolina
(East Carolina University, 2013)The seasonal and interannual variability of midlatitude cyclone structure, frequency, and propagation was studied based on composites of precipitation over North Carolina. This analysis showed significant changes in the ... -
Clinic Staff Adherence to the CDC’s STD Treatment Guidelines: A QI Initiative in a Local Health Department
(2016-07-25)The Orange County Health Department (OCHD), a medium sized health department in central North Carolina, manages many patients for sexually transmitted diseases (STDs) based on the CDC’s STD Treatment Guidelines and guidance ... -
Clinical and echocardiographic predictors of mortality in acute pulmonary embolism
(2016-10-28)Purpose: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism ... -
Clinical assessment of medical students in the Emergency Department, A National Consensus Conference
(2017-01)BACKGROUND The clinical assessment of medical students in the emergency department (ED) is a highly variable process in which clerkship directors (CD) create and use institution-specific tools, many with unproven reliability ... -
Clinical differences between pulmonary and extrapulmonary tuberculosis: a 5-year retrospective study.
(East Carolina University, 1995-03)This article describes the clinical, epidemiologic, laboratory, and treatment characteristics of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in Eastern North Carolina, a primarily rural area. The ... -
Clinical Inquiries: Do preparticipation physical exams reduce morbidity and mortality for athletes?
(East Carolina University, 2005)This article reviews research to determine if preparticipation physical exams reduce morbidity and mortality for athletes. -
Clinical Inquiries: What interventions can help patients stop using chewing tobacco?
(East Carolina University, 2005)This review article examines current literature to recommend interventions to help patients stop using chewing tobacco. -
Clinical Ladder Mentoring: The Impact on Nursing Professional Development
(2019-07-17)Clinical ladder mentorship programs engage registered nurses in professional development, improve job satisfaction, and retention. The aim of this quality improvement project was to foster professional growth in early to ... -
Clinical Outcomes by Race and Ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT): A Randomized Clinical Trial
(2017-08-23)BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) showed that targeting a systolic blood pressure (SBP) of ≤ 120 mm Hg (intensive treatment) reduced cardiovascular disease (CVD) events compared to SBP ... -
Clinical Practice Change: Suboxone Use in Inpatient Psychiatry
(2019-04-26)The opioid epidemic is public health crisis with veterans twice as likely as civilians to die from opioid overdose (National Council on Alcoholism and Drug Dependence [NCADD], 2017). The VA prescribes Suboxone in the ... -
Clinical use of rifampicin during routine reporting of rifampicin susceptibilities: a lesson in selective reporting of antimicrobial susceptibility data
(1997-10)Increased use of rifampicin for in-patients was noted after the laboratory began reporting rifampicin susceptibilities routinely for all Gram-positive bacterial isolates. The appropriateness of rifampicin use was evaluated ...