Browsing by Author "Brown, David A."
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The “Goldilocks Zone� from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
Alleman, Rick J.; Katunga, Lalage Adalaide; Nelson, Margaret A. M.; Brown, David A.; Anderson, Ethan (2014-09)Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ... -
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Alleman, Rick J. (East Carolina University, 2016-05-03)Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ... -
Exercise-Induced Protection Against Reperfusion Arrhythmia Involves Stabilization of Mitochondrial Energetics
Spangenburg, Espen; Alleman, Rick J.; Tsang, Alvin M.; Ryan, Terence E.; Patteson, Daniel J.; McClung, Joseph M.; Shaikh, Saame Raza; Neufer, P. Darrell; Brown, David A. (2016-05-15) -
The "Goldilocks Zone" from a redox perspective-Adaptive vs. deleterious responses to oxidative stress in striated muscle
Alleman, Rick J.; Katunga, Lalage A; Nelson, Margaret A. M.; Brown, David A.; Anderson, Ethan (2014-09-18)Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ... -
Mitochondrial Therapy Improves Limb Perfusion and Myopathy Following Hindlimb Ischemia
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Alleman, Rick J.; Tsang, Alvin M.; Green, Thomas D.; Neufer, P. Darrell; Brown, David A. (2016-08-01) -
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment
McClung, Joseph M.; Reinardy, Jessica L.; Mueller, Sarah B.; McCord, Timothy J.; Kontos, Christopher D.; Brown, David A.; Hussain, Sabah N. A.; Schmidt, Cameron A.; Ryan, Terence E.; Green, Thomas D. (2015-05)Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role ... -
The Physiological and Pathological Role of Mitochondrial Calcium in the Diabetic Heart
Sloan, Ruben C. (East Carolina University, 2011)Diabetic patients are more susceptible to ischemia/reperfusion injury and cardiac dysfunction likely due alterations in mitochondrial calcium handling. The purpose of this work was to determine if redox-dependent changes ... -
Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function
McDaniel, Dylan K.; Ringel-Scaia, Veronica M.; Morrison, Holly A.; Coutermarsh-Ott, Sheryl; Council-Troche, McAlister; Angle, Jonathan W.; Perry, Justin B.; Davis, Grace; Leng, Weinan; Minarchick, Valerie; Yang, Yi; Chen, Bo; Reece, Sky W.; Brown, David A.; Cecere, Thomas E.; Brown, Jared; Gowdy, Kymberly M.; Hochella, Michael F.; Allen, Irving C. (2019-11-28)Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ... -
Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide
Kloner, Robert A.; Hale, Sharon L.; Dai, Wangde; Gorman, Robert C.; Shuto, Takashi; Koomalsingh, Kevin J.; Gorman, Joseph H.; Sloan, Ruben C.; Frasier, Chad R.; Watson, Corinne A.; Bostian, Phillip A.; Kypson, Alan P.; Brown, David A. (2012-06) -
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
Frasier, Chad R. (East Carolina University, 2012)Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ... -
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
Moukdar, Fatiha (East Carolina University, 2014)Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ... -
Why Does Exercise “Trigger� Adaptive Protective Responses in the Heart?
Alleman, Rick J.; Stewart, Luke M.; Tsang, Alvin M.; Brown, David A. (2015-05)Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that ...